CENPE Antibodies

AND CENPE ELISA kits, CENPE Proteins

Many biological assays use antibodies to detect CENPE, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with CENPE in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop CENPE antibodies...

We validate the specificity of these antibodies to CENPE by testing them on tissues known to express CENPE positively and negatively. Browse below to find the CENPE antibody that suites your experiment. We have 3 of these antibodies and many publications and validation images.

If you cannot find antibodies that fit your needs, contact us for making custom antibodies. We have a full suite of custom antibody services covering from research to diagnostic and therapeutic applications.

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CENPE Infographic by Boster Bio

All CENPE Products

Product

Figures

Specificity

Applications

Price

Anti-CENP-E Monoclonal Antibody

Human

IP, IF, WB

$612
Cat # M04553
100ug

Anti-CENPE Monoclonal Antibody

3 Q&As

Human

$370
Cat # M04553-1
100 μl

Anti-Cenpe Antibody Picoband™

Mouse, Rat

ELISA, WB

$370
Cat # A04553-1
100 µg/vial

CENPE Overview

Facts about Centromere-associated protein E.

Centromere-associated protein E (CENPE)

Microtubule plus-end-directed kinetochore motor which has an significant role in chromosome congression, microtubule- kinetochore conjugation and spindle assembly checkpoint activation. Drives chromosome congression (alignment of chromosomes at the spindle equator leading to the formation of the metaphase plate) by mediating the lateral sliding of polar chromosomes along spindle microtubules towards the spindle equator and by helping the establishment and maintenance of connections between kinetochores and spindle microtubules (PubMed:7889940, PubMed:23891108, PubMed:25395579).

The transportation of pole-proximal chromosomes towards the spindle equator is preferred by microtubule tracks which are detyrosinated (PubMed:25908662). Acts as a processive bi-directional tracker of dynamic microtubule tips; following chromosomes have congressed, continues to play an active role in kinetochores, enhancing their connections with dynamic microtubule ends (PubMed:23955301).

Gene Information

Human
Gene Name:	CENPE
Uniprot:	Q02224
Entrez:	1062

Family

Belongs to:

TRAFAC class myosin-kinesin ATPase superfamily

Alternative Names

CENP-E; Centromere autoantigen E (312kD); centromere protein E (312kD); Centromere protein E; centromere protein E, 312kDa; centromere-associated protein E; KIF10; kinesin family member 10; Kinesin-related protein CENPE

Molecular Weight

Mass (kDA):
316.415 kDA

Genomic Context


Human

Location:	4q24
Sequence:	4; NC_000004.12 (103105811..103198408, complement)

Subcellular Localizations

Chromosome, centromere, kinetochore. Cytoplasm, cytoskeleton, spindle. Chromosome, centromere. Associates with kinetochores during congression (as early as prometaphase), relocates to the spindle midzone at anaphase, and is quantitatively discarded at the end of the cell division (By similarity). Recruited to the kinetochore in a SEPT7, CENPQ and TRAPPC12-dependent manner (PubMed:18460473, PubMed:25918224, PubMed:25395579). Recruited to the pericentromeric/centromeric regions of the chromosome in a CTCF-dependent manner (PubMed:26321640).