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- Table of Contents
Crtc2 Antibodies
AND Crtc2 ELISA kits, Crtc2 Proteins
Many biological assays use antibodies to detect Crtc2, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with Crtc2 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop Crtc2 antibodies...
Designing a Western blot for Crtc2? The guide has the expected band size, antibodies backed by real blot images, the controls to run alongside, and protocols taken from published papers.
Open the CRTC2 Western Blot GuideCrtc2 Infographic by Boster Bio
All Crtc2 Products
Product
Figures
Specificity
Applications
Price
Mouse, Rat
ELISA, Flow Cytometry, IF, ICC, WB
$370
Cat # A01123-2
100 µg/vial
Cat # A01123-2
100 µg/vial
Human, Monkey
ELISA, Flow Cytometry, IF, IHC, WB
$380
Cat # M01118
100ul
Cat # M01118
100ul
Crtc2 Overview
Facts about CREB-regulated transcription coactivator 2.
CREB-regulated transcription coactivator 2 (Crtc2)
Transcriptional coactivator for CREB1 which activates transcription via both consensus and variant cAMP response element (CRE) sites. Acts as a coactivator, in the SIK/TORC signaling pathway, being busy when dephosphorylated and acts independently of CREB1'Ser-133' phosphorylation.
Enhances the interaction of CREB1 with TAF4. Regulates gluconeogenesis as a component of the LKB1/AMPK/TORC2 signaling pathway.
Gene Information
| Mouse | |
|---|---|
| Gene Name: | Crtc2 |
| Uniprot: | Q3U182 |
| Entrez: | 74343 |
Family
| Belongs to: |
|---|
| TORC family |
Alternative Names
CREB regulated transcription coactivator 2; CREB-regulated transcription coactivator 2; CRTC2; TORC2; TORC-2; TORC2transducer of regulated cAMP response element-binding protein (CREB) 2; Transducer of CREB protein 2; Transducer of regulated cAMP response element-binding protein 2
Molecular Weight
Mass (kDA):
73.216 kDA
Genomic Context
| Mouse | |
|---|---|
| Location: | 3|3 F1 |
| Sequence: | 3; |
Tissue Specificity
Expressed in the suprachiasmatic nucleus (SCN) of the brain.
Diseases
- Malignant Neoplasms
- Neoplasms
- Diabetes Mellitus
- Leukemia
- Insulin Resistance
- Sclerosis
- Diabetes Mellitus, Non-insulin-dependent
- Cell Transformation, Neoplastic
- Tuberous Sclerosis
- Obesity
- Hyperglycemia
- Malignant Paraganglionic Neoplasm
Pathways
- Cell Growth
- Cell Proliferation
- Gluconeogenesis
- Translation
- Localization
- Cell Cycle
- Autophagy
- Glucose Homeostasis
- Cell Differentiation
- Angiogenesis
- Cell Death
- Rna Interference
- Transport
PTMs
- Phosphorylation
- Dephosphorylation
- Ubiquitination
- Cleavage
Research Areas
- Cancer
- Hypoxia
- Lipid and Metabolism
- Signal Transduction
- Transcription Factors and Regulators
For details, visit:
bosterbio.com/bosterbio-gene-info-cards/Crtc2
bosterbio.com/bosterbio-gene-info-cards/Crtc2
References
PMID: 16148943 by Koo S.-H., et al. The CREB coactivator TORC2 is a key regulator of fasting glucose metabolism.
PMID: 16308421 by Shaw R.J., et al. The kinase LKB1 mediates glucose homeostasis in liver and therapeutic effects of metformin.