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Product Info Summary
| SKU: | A01118 |
|---|---|
| Size: | 0.1 mg |
| Reactive Species: | Human, Mouse, Rat |
| Host: | Rabbit |
| Application: | ELISA, IF, IHC-P, WB |
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Product info
Product Name
Anti-CRTC2 Antibody
SKU/Catalog Number
A01118
Size
0.1 mg
Form
Liquid
Description
Boster Bio Anti-CRTC2 Antibody (Catalog # A01118). Tested in ELISA, WB, IHC-P, IF applications. This antibody reacts with Human, Mouse, Rat.
Storage & Handling
CRTC2 antibody can be stored at 4°C for three months and -20°C, stable for up to one year.
Cite This Product
Anti-CRTC2 Antibody (Boster Biological Technology, Pleasanton CA, USA, Catalog # A01118)
Host
Rabbit
Contents
CRTC2 Antibody is supplied in PBS containing 0.02% sodium azide.
Clonality
Polyclonal
Isotype
IgG
Immunogen
CRTC2 antibody was raised against a 16 amino acid peptide near the carboxy terminus of human CRTC2. The immunogen is located within the last 50 amino acids of CRTC2.
Cross-reactivity
Multiple isoforms of CRTC2 are known to exist. CRTC2 antibody is predicted to not cross-react with CRTC1.
Reactive Species
A01118 is reactive to CRTC2 in Human, Mouse, Rat
Observed Molecular Weight
68 kDa
Calculated molecular weight
73.3 kDa
Background of CRTC2
CRTC2, also known as TORC2 (Transducers Of Regulated cAMP Response Element-Binding (CREB)) 2 and the related protein CRTC1 are potent CREB coactivators that are exported from the nucleus in a CRM1-dependent manner via phosphorylation-dependent interactions. Studies suggest that their phosphorylation and nuclear/cytoplasmic shuttling play an important role in the regulation of gluconeogenesis by cAMP. CRTC2 is present in both B and T-lymphocytes and abundantly expressed in the thymus. Its activity is important in regulating the expression of genes involved in cellular energy metabolism while CRTC1 is essential for energy balance and fertility.
Antibody Validation
Boster validates all antibodies on WB, IHC, ICC, Immunofluorescence, and ELISA with known positive control and negative samples to ensure specificity and high affinity, including thorough antibody incubations.
Application & Images
Applications
A01118 is guaranteed for ELISA, IF, IHC-P, WB Boster Guarantee
Assay Dilutions Recommendation
The recommendations below provide a starting point for assay optimization. The actual working concentration varies and should be decided by the user.
CRTC2 antibody can be used for detection of CRTC2 by Western blot at 1 - 2 μg/mL.
Antibody validated: Western Blot in human samples; Immunohistochemistry in human samples and Immunofluorescence in human samples. All other applications and species not yet tested. Optimal dilutions for each application should be determined by the researcher.
Validation Images & Assay Conditions
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Western blot analysis of CRTC2 in human small intestine tissue lysate with CRTC2 antibody at (A) 0.5 and (B) 1 μg/mL.
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Immunohistochemistry of CRTC2 in human small intestine tissue with CRTC2 antibody at 2.5 μg/ml.
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Immunofluorescence of CRTC2 in human small intestine tissue with CRTC2 antibody at 20 μg/ml.
Specific Publications For Anti-CRTC2 Antibody (A01118)
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