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- Table of Contents
Facts about Disks large homolog 1.
May play a role in adherens junction assembly, signal transduction, cell proliferation, synaptogenesis and lymphocyte activation. Regulates the excitability of cardiac myocytes by regulating the functional expression of Kv4 channels.
Human | |
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Gene Name: | DLG1 |
Uniprot: | Q12959 |
Entrez: | 1739 |
Belongs to: |
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MAGUK family |
discs, large homolog 1 (Drosophila); disks large homolog 1; DKFZp761P0818; DKFZp781B0426; hDlg; large (Drosophila) homolog 1; presynaptic protein SAP97
Mass (kDA):
100.455 kDA
Human | |
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Location: | 3q29 |
Sequence: | 3; NC_000003.12 (197042560..197299321, complement) |
Abundantly expressed in atrial myocardium (at protein level). Expressed in lung fibroblasts, cervical epithelial and B-cells (at protein level). Widely expressed, with isoforms displaying different expression profiles.
Membrane; Peripheral membrane protein. Basolateral cell membrane. Endoplasmic reticulum membrane. Cell junction, synapse, postsynaptic density. Cell junction, synapse. Cell membrane, sarcolemma. Apical cell membrane. Cell junction. Cytoplasm. Colocalizes with EPB41 at regions of intercellular contacts. Basolateral in epithelial cells (PubMed:12807908). May also associate with endoplasmic reticulum membranes. Mainly found in neurons soma, moderately found at postsynaptic densities (By similarity).
PMID: 7937897 by Lue R.A., et al. Cloning and characterization of hdlg: the human homologue of the Drosophila discs large tumor suppressor binds to protein 4.1.
PMID: 7477295 by Kim E., et al. Clustering of Shaker-type K+ channels by interaction with a family of membrane-associated guanylate kinases.