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May also phosphorylate PPP1R12A and inhibit the myosin phosphatase activity to modulate myosin phosphorylation. Also vital to the modulation of cardiac contractility and to the maintenance of appropriate cardiac conduction activity likely through the regulation of cellular calcium homeostasis.
|protein kinase superfamily|
|Sequence:||19; NC_000019.10 (45769709..45782490, complement)|
Most isoforms are expressed in many tissues including heart, skeletal muscle, liver and brain, except for isoform 2 which is only found in the heart and skeletal muscle, and isoform 14 which is only found in the brain, with high levels in the striatum, cerebellar cortex and pons.
Endoplasmic reticulum membrane; Single-pass type IV membrane protein; Cytoplasmic side. Nucleus outer membrane; Single-pass type IV membrane protein; Cytoplasmic side. Mitochondrion outer membrane; Single-pass type IV membrane protein. Sarcoplasmic reticulum membrane. Cell membrane. Cytoplasm, cytosol. Localizes to sarcoplasmic reticulum membranes of cardiomyocytes.; [Isoform 1]: Mitochondrion membrane.; [Isoform 3]: Mitochondrion membrane.