Anti-Myotonin-protein kinase DMPK Antibody

Product Name

Anti-Myotonin-protein kinase DMPK Antibody

View all DMPK Antibodies

SKU/Catalog Number

A00797

Size

100μl

Form

Liquid

Description

Boster Bio Anti-Myotonin-protein kinase DMPK Antibody catalog # A00797. Tested in WB applications. This antibody reacts with Human.

Storage & Handling

Store at -20°C for one year. For short term storage and frequent use, store at 4°C for up to one month. Avoid repeated freeze-thaw cycles.

Cite This Product

Anti-Myotonin-protein kinase DMPK Antibody (Boster Biological Technology, Pleasanton CA, USA, Catalog # A00797)

Host

Rabbit

Contents

Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Clonality

Polyclonal

Isotype

IgG

Immunogen

Synthesized peptide derived from the N-terminal region of human DMPK. at AA rangle: 30-110

*Blocking peptide can be purchased. Costs vary based on immunogen length. Contact us for pricing.

Cross-reactivity

No cross reactivity with other proteins.

Reactive Species

A00797 is reactive to DMPK in Human

Applications

A00797 is guaranteed for WB Boster Guarantee

Observed Molecular Weight

39 kDa

Calculated molecular weight

69.385kDa

Background of DMPK

Signaling adapter that couples activated growth factor receptors to signaling pathway. Isoform p46Shc and isoform p52Shc, once phosphorylated, couple activated receptor tyrosine kinases to Ras via the recruitment of the GRB2/SOS complex and are implicated in the cytoplasmic propagation of mitogenic signals. Isoform p46Shc and isoform p52Shc may thus function as initiators of the Ras signaling cascade in various non-neuronal systems. Isoform p66Shc does not mediate Ras activation, but is involved in signal transduction pathways that regulate the cellular response to oxidative stress and life span. Isoform p66Shc acts as a downstream target of the tumor suppressor p53 and is indispensable for the ability of stress-activated p53 to induce elevation of intracellular oxidants, cytochrome c release and apoptosis. The expression of isoform p66Shc has been correlated with life span

Trampont P, et al. (2006) Mol Cell Biol; 26(23): 9035-9044.
Patrussi L, et al. (2005) Oncogene; 24(13): 2218-2228
van der Geer P, et al. (1996) Curr Biol ; 6(11): 1435-1444

Antibody Validation

Boster validates all antibodies on WB, IHC, ICC, Immunofluorescence, and ELISA with known positive control and negative samples to ensure specificity and high affinity, including thorough antibody incubations.

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Assay Dilutions Recommendation

The recommendations below provide a starting point for assay optimization. The actual working concentration varies and should be decided by the user.

WB, 1:500-1:2000

Validation Images & Assay Conditions

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Western Blot (WB) analysis of Jurkat cells using DMPK Polyclonal antibody.

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Western Blot (WB) analysis of specific cells using DMPK Polyclonal antibody.

Gene/Protein Information For DMPK (Source: Uniprot.org, NCBI)

Alternative Names

DM1; DM1PK; DMK; DMKEC 2.7.11.1; DM-kinase; DMmyotonin protein kinase A; DMPK; dystrophia myotonica-protein kinase; MDPK; MDPKDM protein kinase; MT-PK; MT-PKmyotonic dystrophy associated protein kinase; Myotonic dystrophy protein kinase; myotonin-protein kinase; thymopoietin homolog DMPK DM, DM1, DM1PK, DMK, MDPK, MT-PK DM1 protein kinase myotonin-protein kinase|DM protein kinase|dystrophia myotonica protein kinase|myotonic dystrophy associated protein kinase|myotonin protein kinase A|thymopoietin homolog

For more info on DMPK, check out the DMPK Infographic

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In this infographic, you will see the following information for DMPK: database IDs, superfamily, protein function, synonyms, molecular weight, chromosomal locations, tissues of expression, subcellular locations, post-translational modifications, and related diseases, research areas & pathways. If you want to see more information included, or would like to contribute to it and be acknowledged, please contact [email protected].

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