DYNC1H1 Antibodies

AND DYNC1H1 ELISA kits, DYNC1H1 Proteins

Many biological assays use antibodies to detect DYNC1H1, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with DYNC1H1 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop DYNC1H1 antibodies...

We validate the specificity of these antibodies to DYNC1H1 by testing them on tissues known to express DYNC1H1 positively and negatively. Browse below to find the DYNC1H1 antibody that suites your experiment. We have 3 of these antibodies and many publications and validation images.

If you cannot find antibodies that fit your needs, contact us for making custom antibodies. We have a full suite of custom antibody services covering from research to diagnostic and therapeutic applications.

Designing a Western blot for DYNC1H1? The guide has the expected band size, antibodies backed by real blot images, the controls to run alongside, and protocols taken from published papers.

Open the DYNC1H1 Western Blot Guide

DYNC1H1 Infographic by Boster Bio

All DYNC1H1 Products

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Applications

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Anti-DYNC1H1 Antibody (C-term)

All lanes : Anti-DYNC1H1 Antibody (C-term) at 1:2000 dilutionLane 1: A431 whole cell lysateLane 2: PC-3 whole cell lysateLane 3: mouse brain lysateLysates/proteins at 20 µg per lane

M03059 staining DYNC1H1 in human testis sections by Immunohistochemistry (IHC-P -paraformaldehyde-fixed, paraffin-embedded sections)

Human, Mouse

IHC-P, WB

$299
Cat # M03059
80 µl

Anti-DYNC1H1 Antibody

Human, Mouse

ELISA, IHC

$370
Cat # A03059-2
100 μg/vial

Anti-DYNC1H1 Antibody (C-term)

Western blot analysis of lysates from Hela, PC-3 cell line and rat brain tissue lysate (from left to right), using DYNC1H1 Antibody (C-term)

Human, Rat

$299
Cat # A03059-1
80 µl

DYNC1H1 Overview

Facts about Cytoplasmic dynein 1 heavy chain 1.

Cytoplasmic dynein 1 heavy chain 1 (DYNC1H1)

Cytoplasmic dynein 1 acts as a motor for its intracellular retrograde motility of vesicles and organelles along microtubules. Dynein has ATPase activity; the force-producing power stroke is supposed to occur on release of ADP.

Plays a role in mitotic spindle assembly and metaphase plate congression (PubMed:27462074). .

Gene Information

Human
Gene Name:	DYNC1H1
Uniprot:	Q14204
Entrez:	1778

Family

Belongs to:

dynein heavy chain family

Alternative Names

cytoplasmic dynein 1 heavy chain 1; Cytoplasmic dynein heavy chain 1; DHC1a; DHC1Dynein heavy chain, cytosolic; DKFZp686P2245; Dnchc1; DNCLDNCH1; DNECLDYHC; dynein, cytoplasmic 1, heavy chain 1; dynein, cytoplasmic, heavy polypeptide 1; HL-3; KIAA0325; p22

Molecular Weight

Mass (kDA):
532.408 kDA

Genomic Context


Human

Location:	14q32.31
Sequence:	14; NC_000014.9 (101964573..102056443)

Subcellular Localizations

Cytoplasm, cytoskeleton.

Diseases

Amyotrophic Lateral Sclerosis
Motor Neuron Disease
Neurodegenerative Disorders
Nerve Degeneration
Sclerosis
Primary Lateral Sclerosis
Charcot-marie-tooth Disease
Spinal Muscular Atrophy
Muscular Atrophy
Atrophy
Spinal Muscular Atrophies Of Childhood

Congenital Abnormality
Sensory Neuropathy
Classical Lissencephaly
Weakness
Spastic Paraplegia, Hereditary
Sensation Disorders

Interacting Proteins

DISC1
HTT
PSEN2

Pathways

Transport
Pathogenesis
Intracellular Transport
Synapse Assembly
Intraflagellar Transport
Proprioception
Localization

Reflex
Myelination

PTMs

Phosphorylation

Research Areas

Cell Cycle and Replication

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/DYNC1H1

References

PMID: 8666668 by Vaisberg E.A., et al. Mammalian cells express three distinct dynein heavy chains that are localized to different cytoplasmic organelles.

PMID: 8227145 by Vaisberg E.A., et al. Cytoplasmic dynein plays a role in mammalian mitotic spindle formation.