Transcription factor E2F1 (E2F1)

Transcription activator that binds DNA cooperatively with DP proteins through the E2 recognition site, 5'-TTTC[CG]CGC- 3' found in the promoter region of a number of genes whose products are involved in cell cycle regulation or in DNA replication. The DRTF1/E2F complex functions in the control of cell-cycle progression from G1 to S phase.

E2F1 binds preferentially RB1 in a cell-cycle dependent way. It can mediate both cell proliferation and TP53/p53-dependent apoptosis.