FBP1 Antibodies

Fructose-1,6-bisphosphatase 1 (FBP1)

Catalyzes the hydrolysis of fructose 1,6-bisphosphate to fructose 6-phosphate in the presence of divalent cations, acting as a rate-limiting enzyme in gluconeogenesis. Plays a role in regulating glucose sensing and insulin secretion of pancreatic beta-cells.

Appears to modulate glycerol gluconeogenesis in liver. Significant regulator of appetite and adiposity; increased expression of the protein in liver after nutrient surplus raises circulating satiety hormones and reduces appetite-stimulating neuropeptides and so seems to provide a feedback mechanism to limit weight gain.

Gene Information

Human
Gene Name:	FBP1
Uniprot:	P09467
Entrez:	2203

Family

Belongs to:
FBPase class 1 family

Alternative Names

D-fructose-1,6-bisphosphate 1-phosphohydrolase 1; EC 3.1.3; EC 3.1.3.11; FBP; FBP1; FBPase 1; fructose-1,6-bisphosphatase 1; fructose-bisphosphatase 1; growth-inhibiting protein 17

Molecular Weight

Mass (kDA):
36.842 kDA

Genomic Context

Human
Location:	9q22.32
Sequence:	9; NC_000009.12 (94603133..94640263, complement)

Tissue Specificity

Expressed in pancreatic islets.

Diseases

• Malignant Neoplasms
• Neoplasms
• Carcinoma
• Hypoglycemia
• Liver Carcinoma
• Malignant Neoplasm Of Breast
• Acidosis
• Diabetes Mellitus
• Diabetes Mellitus, Non-insulin-dependent
• Fructose-1,6-diphosphatase Deficiency
• Liver Neoplasms
• Leukemia

• Hepatocarcinogenesis
• Prostatic Neoplasms
• Malignant Neoplasm Of Prostate
• Malignant Neoplasm Of Stomach
• Drug-induced Liver Injury
• Mammary Neoplasms

Interacting Proteins

• BIN1
• EPAS1
• FBP2
• HIF1A

Pathways

• Gluconeogenesis
• Glycolysis
• Glyoxylate Cycle
• Chromatin Remodeling
• Translation
• Cell Growth
• Mating
• Cell Proliferation
• Virulence
• Cell Cycle
• Localization
• Pathogenesis
• Regulation Of Gene Expression

• Oxidative Phosphorylation
• Sporulation
• Meiosis
• Conjugation
• Methylation
• Secretion
• Neural Tube Closure

PTMs

• Phosphorylation
• Methylation
• Demethylation
• Glycosylation
• Oxidation

• Ubiquitination
• Biotinylation
• Cleavage
• Amidation
• Acetylation

• Dephosphorylation

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/FBP1

Boster Bio - Best Uses Of The FBP1 Marker

You may be a beginner to boster biology and wonder how to make the most of the FBP1 marker. This guide will demonstrate how to use FBP1 to improve your experiments. You can also read the Boster Bio optimization tips and guides to learn more about the optimization process and how to optimize your experiment. Here are some example:

HK-fbp1 vaccine

After several people became ill, Hong Kong stopped using a particular batch of Pfizer BioNTech shots. The vaccine's packaging was defective and the vaccination was stopped. Hong Kong has since sought out answers from BioNTech as well as Fosun Pharma. The company stated that the problem was isolated and did no pose a risk to the safety of the population. Since the outbreak in an older residential building, Hong Kong has already seen thousands of coronavirus-related cases.

The HKFBP1 vaccine provides significant protection against this disease. Researchers used the vaccine three to six weeks after receiving the second inactivated vaccine. It was administered at 200 participants in a clinical experiment. The HK-fbp1 vaccine produced significant levels of antibody response. The vaccine was also administered in a booster dose three to six months after the second inactivated vaccination.

In a clinical study, the HK fbp1 vaccination showed minimal inflammation and fungal load, while the HK fbp1D deleted mutant had minimal fungal load. The experiment revealed that interleukin-17 and IFNg were the main cytokine producers. Boster Bio believes that the vaccine will provide significant protection for people who need it. However, further studies are necessary to determine its efficacy in humans.

A recent study also showed that the HK-fbp1 vaccine induced strong immune responses in mice. The HK-fbp1 vaccine elicited strong immune responses against H99 wild-type strains, but the HKfbp1 mutant didn't produce these responses. The researchers concluded that Fbp1 is crucial for the development of cryptococcococcococcosis.

HK-fbp1 vaccine against Cryptococcus

The HK-fbp1 vaccine against the fungus is a promising approach to protect against cryptococcal infections. It is composed a monoclonal antibody that targets Cryptococcus neonatal capsular polysaccharide. It is currently being developed in several studies to assess its safety and efficacy. It is also being used in clinical trials for safety and effectiveness.

A number of factors affect the protection of the host against cryptococcal infections. In animal models of Cryptococcosis, the role of CD4+T cell is underlined. CD4+T cells trigger an immune response which recruits phagocytes in order to clear the infection. A strong IFNg response in cryptococcosis patients is associated with a positive outlook.

Comparative genomic analysis of the three C. Neoformans isolates has revealed significant differences between their virulence genes, and stress responses. CCK2 is an antifungal drug that encodes caseinkinase. The capsule production and thermotolerance of the later-stage isolates was enhanced. A comparative analysis of the isolates revealed that some HK-fbp1 vaccines showed improved protection against cryptococcal infections.

Another study in mice demonstrated that heat-killed mutant Cryptococcus strains of Cryptococcus can induce strong T helper-1 cell responses. This provides protection against the Cryptococcal infection. To maximize protection, a vaccine must include the right adjuvants and antigen delivery systems. Glucan particles have shown great promise as delivery systems for a cryptococcal vaccine. Glucan particles were shown to provide sustained protection against Cryptococcus infection in mice that were vaccinated.

Inflammatory processes in the body are also involved in the transmission of Cryptococcus infection. Inflammation in the lungs can stimulate the growth of yeast cells and may also stimulate the production of antibodies against them. To prevent the spread and spread of Cryptococcal disease, it is essential that Th cell differentiation and larger particles are ingested. Inflammation of the lungs can reduce the immune system’s ability to fight off Cryptococcus.

Phospholipase B1 (a fungus protein) is secreted during infection by Cryptococcus cells. It is involved during invasion, maintains fungal cell walls integrity, and damages host cell membranes. In addition, PLB1 mutants exhibit attenuated virulence and weakened titan cell formation in mice. These results are encouraging and suggest the need for a vaccine against Cryptococcus.

HK-fbp1 vaccine against H99

Boster Bio’s HK-fbp1 vaccine was effective in protecting mice against Haemophilus avium type b (H99). Infected mice that had the fbp1D variant were symptomatic 60-days after infection. This was compared to 20-25 days in wild-type H99. In the study, no yeast cells were recovered from the brains or spleens of mice infected with the H99 mutant strain. The wild-type strain produced 108 CFUs in each lung of those infected.

Mice infected with heat-killed FBP1D deletion mutants were able to develop 100% immunity against the virulent H99. These mice survived for 60 days without succumbing to infection. The only effective vaccine composition contains heat-killed H99 fbp1D mutants. Boster Bio's HK fbp1 vaccine against the H99 is an excellent choice to protect against this disease.

This study was able identify two mutant strains. The intracellular growth rate of the fbp1D mutation was 25 times less than wild-type H99 cell lines. The researchers were able to observe the replication of yeast cells inside macrophages in real time and noted that the mutant strain proliferated at a slower rate than the wild-type H99 cells.

This invention is based on an unexpected discovery of mutants inactivating fbp1D, which confer immunity against infection by virulent h99 yeast. These inactivated mutants of fbp1D were also found to induce robust immune responses that are resistant to the parental H99 strain. These findings highlight the potential of this vaccine to provide protection against other fungal species.

The HK fbp1 gene is highly conserved among fungi. This is why the NK fbp1 mutants are immune to infection. Nonetheless, this does not mean that fbp1D mutations are harmless to humans. Boster Bio has conducted several studies on fbp1 mutants and developed a genetically modified H99 strain that will confer protection against H99.