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May also activate monocytes via a G protein-coupled receptor, FFAR2, inducing the secretion of interleukin-8/IL-8 (PubMed:21037097). Binds preferentially to 9-O-acetylated 2-6- linked sialic acid derivatives and to various glycans containing sialic acid participated in a 2-3 linkage.
|ficolin lectin family|
|Sequence:||9; NC_000009.12 (134903232..134917912, complement)|
Peripheral blood leukocytes, monocytes and granulocytes. Also detected in spleen, lung, and thymus, may be due to the presence of tissue macrophages or trapped blood in these tissues. Not detected on lymphocytes.
Secreted. Cell membrane; Peripheral membrane protein; Extracellular side. Found on the monocyte and granulocyte surface (PubMed:20400674).