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- Table of Contents
Granzyme A Antibodies
AND GZMA ELISA kits, Granzyme A Proteins
Many biological assays use antibodies to detect Granzyme A, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with Granzyme A in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop Granzyme A antibodies...
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GZMA Infographic by Boster Bio
All GZMA Products
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Human Granzyme A ELISA Kit PicoKine®
2 Citations 6 Q&As
Human
ELISA
$499
Cat # EK1162
96 wells/kit, with removable strips.
Cat # EK1162
96 wells/kit, with removable strips.
GZMA Overview
Facts about Granzyme A.
Granzyme A (GZMA)
Abundant protease from the cytosolic granules of cytotoxic T-cells and NK-cells which activates caspase-independent cell death with morphological features of apoptosis when delivered to the target cell during the immunological synapse. It cleaves after Lys or Arg.
Cleaves APEX1 after'Lys-31' and destroys its oxidative repair action. Cleaves the nucleosome assembly protein SET after 'Lys-189', which disrupts its nucleosome assembly activity and allows the SET complex to translocate into the nucleus to nick and degrade the DNA.
Gene Information
| Human | |
|---|---|
| Gene Name: | GZMA |
| Uniprot: | P12544 |
| Entrez: | 3001 |
Family
| Belongs to: |
|---|
| peptidase S1 family |
Alternative Names
CTL Tryptase; CTLA3; CTLA3Granzyme A (Cytotoxic T-lymphocyte-associated serine esterase-3; Hanukah factorserine protease); Cytotoxic T-lymphocyte proteinase 1; EC 3.4.21; Fragmentin-1; granzyme A (granzyme 1, cytotoxic T-lymphocyte-associated serine esterase 3); Granzyme A; Granzyme-1; GZMA; H factor; Hanukkah factor; HF; HFSP; HFSPEC 3.4.21.78
Molecular Weight
Mass (kDA):
28.999 kDA
Genomic Context
| Human | |
|---|---|
| Location: | 5q11.2 |
| Sequence: | 5; NC_000005.10 (55102646..55110252) |
Subcellular Localizations
[Isoform alpha]: Secreted. Cytoplasmic granule.
Diseases
- Neoplasms
- Infective Disorder
- Virus Diseases
- Leukemia
- Rheumatoid Arthritis
- Hiv Infections
- Malignant Neoplasms
- Arthritis
- Immunologic Deficiency Syndromes
- Inflammation
- Tissue Adhesions
- Autoimmune Reaction
- Lymphoma
Pathways
- Cell Death
- Exocytosis
- Secretion
- Cytolysis
- Pathogenesis
- Immune Response
- Proteolysis
- Cell Proliferation
- Cell Killing
- Programmed Cell Death
- Induction Of Apoptosis
- Localization
- Nucleosome Assembly
PTMs
- Cleavage
- Phosphorylation
- Myristoylation
- Sulphation
- Reduction
For details, visit:
bosterbio.com/bosterbio-gene-info-cards/GZMA
bosterbio.com/bosterbio-gene-info-cards/GZMA
References
PMID: 3257574 by Gershenfeld H.K., et al. Cloning and chromosomal assignment of a human cDNA encoding a T cell- and natural killer cell-specific trypsin-like serine protease.
PMID: 17180578 by Ruike Y., et al. Glucocorticoid-induced alternative promoter usage for a novel 5' variant of granzyme A.