Granzyme A (GZMA)

Abundant protease from the cytosolic granules of cytotoxic T-cells and NK-cells which activates caspase-independent cell death with morphological features of apoptosis when delivered to the target cell during the immunological synapse. It cleaves after Lys or Arg.

Cleaves APEX1 after'Lys-31' and destroys its oxidative repair action. Cleaves the nucleosome assembly protein SET after 'Lys-189', which disrupts its nucleosome assembly activity and allows the SET complex to translocate into the nucleus to nick and degrade the DNA.