Anti-Granzyme A GZMA Antibody

Granzyme A antibody

Boster Bio Anti-Granzyme A GZMA Antibody catalog # A02779. Tested in WB,IF applications. This antibody reacts with Human,Mouse,Rat.

Product Info Summary

SKU: A02779
Size: 100ul
Reactive Species: Human, Mouse, Rat
Host: Rabbit
Application: IF, WB

Product Name

Anti-Granzyme A GZMA Antibody

View all Granzyme A Antibodies

SKU/Catalog Number

A02779

Size

100ul

Form

Liquid

Description

Boster Bio Anti-Granzyme A GZMA Antibody catalog # A02779. Tested in WB,IF applications. This antibody reacts with Human,Mouse,Rat.

Storage & Handling

Store at -20°C for one year. For short term storage and frequent use, store at 4°C for up to one month. Avoid repeated freeze-thaw cycles.

Cite This Product

Anti-Granzyme A GZMA Antibody (Boster Biological Technology, Pleasanton CA, USA, Catalog # A02779)

Host

Rabbit

Contents

Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

Clonality

Polyclonal

Isotype

IgG

Immunogen

Synthesized peptide derived from human Bcl-3

*Blocking peptide can be purchased. Costs vary based on immunogen length. Contact us for pricing.

Reactive Species

A02779 is reactive to GZMA in Human, Mouse, Rat

Applications

A02779 is guaranteed for IF, WB Boster Guarantee

Observed Molecular Weight

Calculated molecular weight

28.999kDa

Background of Granzyme A

AMP/ATP-binding subunit of AMP-activated protein kinase (AMPK), an energy sensor protein kinase that plays a key role in regulating cellular energy metabolism. In response to reduction of intracellular ATP levels, AMPK activates energy-producing pathways and inhibits energy-consuming processes: inhibits protein, carbohydrate and lipid biosynthesis, as well as cell growth and proliferation. AMPK acts via direct phosphorylation of metabolic enzymes, and by longer-term effects via phosphorylation of transcription regulators. Also acts as a regulator of cellular polarity by remodeling the actin cytoskeleton; probably by indirectly activating myosin. Gamma non-catalytic subunit mediates binding to AMP, ADP and ATP, leading to activate or inhibit AMPK: AMP-binding results in allosteric activation of alpha catalytic subunit (PRKAA1 or PRKAA2) both by inducing phosphorylation and preventing dephosphorylation of catalytic subunits. ADP also stimulates phosphorylation, without stimulating already phosphorylated catalytic subunit. ATP promotes dephosphorylation of catalytic subunit, rendering the AMPK enzyme inactive.

Cheung P.C.F., Biochem. J. 346:659-669(2000).
Lang T.M., Genomics 70:258-263(2000).
Ota T., Nat. Genet. 36:40-45(2004).

Antibody Validation

Boster validates all antibodies on WB, IHC, ICC, Immunofluorescence, and ELISA with known positive control and negative samples to ensure specificity and high affinity, including thorough antibody incubations.

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Assay Dilutions Recommendation

The recommendations below provide a starting point for assay optimization. The actual working concentration varies and should be decided by the user.

WB: 1:500-1:2000
IF: 1:50-1:200

Validation Images & Assay Conditions

Gene/Protein Information For GZMA (Source: Uniprot.org, NCBI)

Gene Name

GZMA

Full Name

Granzyme A

Weight

28.999kDa

Superfamily

peptidase S1 family

Alternative Names

CTL Tryptase; CTLA3; CTLA3Granzyme A (Cytotoxic T-lymphocyte-associated serine esterase-3; Hanukah factorserine protease); Cytotoxic T-lymphocyte proteinase 1; EC 3.4.21; Fragmentin-1; granzyme A (granzyme 1, cytotoxic T-lymphocyte-associated serine esterase 3); Granzyme A; Granzyme-1; GZMA; H factor; Hanukkah factor; HF; HFSP; HFSPEC 3.4.21.78 GZMA CTLA3, HFSP granzyme A granzyme A|CTL tryptase|Cytotoxic T-lymphocyte-associated serine esterase-3|Granzyme A (Cytotoxic T-lymphocyte-associated serine esterase-3; Hanukah factor serine protease)|HF|Hanukah factor serine protease)|cytotoxic T-lymphocyte proteinase 1|fragmentin-1|granzyme 1|granzyme A (granzyme 1, cytotoxic T-lymphocyte-associated serine esterase 3)|h factor

*If product is indicated to react with multiple species, protein info is based on the gene entry specified above in "Species".

For more info on GZMA, check out the GZMA Infographic

GZMA infographic

We have 30,000+ of these available, one for each gene! Check them out.

In this infographic, you will see the following information for GZMA: database IDs, superfamily, protein function, synonyms, molecular weight, chromosomal locations, tissues of expression, subcellular locations, post-translational modifications, and related diseases, research areas & pathways. If you want to see more information included, or would like to contribute to it and be acknowledged, please contact [email protected].

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Order DetailsPrice
A02779-100ul

100ul

$405

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