Glyceraldehyde-3-phosphate dehydrogenase (GAPDH)

Has both glyceraldehyde-3-phosphate dehydrogenase and nitrosylase actions, thereby playing a role in glycolysis and nuclear functions, respectively. Participates in nuclear events such as transcription, RNA transport, DNA replication and apoptosis.

Nuclear functions are probably due to the nitrosylase activity that mediates cysteine S-nitrosylation of nuclear target proteins such as SIRT1, HDAC2 and PRKDC. Facilitates the CHP1-dependent microtubule and membrane associations through its capacity to stimulate the binding of CHP1 into microtubules (By similarity).