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- Table of Contents
Facts about Heparan sulfate glucosamine 3-O-sulfotransferase 3B1.
The substrate-specific O-sulfation creates an enzyme-modified heparan sulfate which acts as a binding receptor into Herpes simplex virus-1 (HSV-1) and allows its entrance. Unlike 3-OST-1, does not convert non- anticoagulant heparan sulfate to anticoagulant heparan sulfate.
Human | |
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Gene Name: | HS3ST3B1 |
Uniprot: | Q9Y662 |
Entrez: | 9953 |
Belongs to: |
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sulfotransferase 1 family |
3OST3B1; h3-OST-3B; heparan sulfate (glucosamine) 3-O-sulfotransferase 3B1; Heparan Sulfate Glucosamine 3OSulfotransferase 3; HS3ST3B1
Mass (kDA):
43.324 kDA
Human | |
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Location: | 17p12 |
Sequence: | 17; NC_000017.11 (14301081..14349406) |
Ubiquitous. Most abundant in liver and placenta, followed by heart and kidney.
Golgi apparatus membrane; Single-pass type II membrane protein.
PMID: 9988767 by Shworak N.W., et al. Multiple isoforms of heparan sulfate D-glucosaminyl 3-O- sulfotransferase. Isolation, characterization, and expression of human cDNAs and identification of distinct genomic loci.
PMID: 10520990 by Shukla D., et al. A novel role for 3-O-sulfated heparan sulfate in herpes simplex virus 1 entry.