Interleukin-17C Antibodies

Interleukin-17C (IL17C)

Cytokine that plays a important role in innate immunity of the epithelium, including to intestinal bacterial pathogens, in an autocrine manner. Stimulates the production of antibacterial peptides and proinflammatory molecules for host defense by signaling through the NF-kappa-B and MAPK pathways.

Acts synergically with IL22 in inducing the expression of antibacterial peptides, including S100A8, S100A9, REG3A and REG3G. Synergy can be observed with TNF and IL1B in inducing DEFB2 from keratinocytes.

Gene Information

Human
Gene Name:	IL17C
Uniprot:	Q9P0M4
Entrez:	27189

Family

Belongs to:
IL-17 family

Alternative Names

CX2; Cytokine CX2; IL17C; IL-17C; IL-17CMGC126884; interleukin 17C; interleukin-17C; MGC138401

Molecular Weight

Mass (kDA):
21.765 kDA

Genomic Context

Human
Location:	16q24.2
Sequence:	16; NC_000016.10 (88638572..88640468)

Subcellular Localizations

Secreted.

Diseases

• Arthritis
• Leprosy
• Erythema
• Collagen Arthritis
• Rheumatoid Arthritis
• Leprosy, Lepromatous

Pathways

• Cell Proliferation
• T Cell Proliferation
• Pathogenesis

PTMs

• Disulfide bond

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/IL17C

Best Uses Of The IL-17C Marker From Boster Bio

You may be interested in the IL-17C protein. This protein is used for a variety of purposes in the field of biology. This gene can be used to determine the location of cells in your body. You can also learn about its relatives IL-17B and IL-17D. These proteins are linked to numerous diseases, including leukemia. Nearly every cancer is IL-17C-positive.

IL-17C

If you're trying to determine if your patient is suffering from an inflammatory disorder It may be beneficial to request a test that detects the presence of IL-17C. The gene that codes for this marker is located on activated T cells. It plays a crucial role in the regulation of NF-kappaB activation and mitogen-activated proteins kinases. Boster has validated the antibody for specificity and affinity to IL-17A and IL-17C. This antibody can also be used to identify IL-17A in multiple sclerosis patients.

IL-17A markers and IL-17C marker are helpful in detecting various diseases. IL-17A and IL-17C play a significant role in the defense of the host against extracellular pathogens and also promote inflammatory pathology in auto-immune diseases. IL-17F and IL-17E also play important roles in the mucosal host defense. IL-17A is a key player in triggering the Th2 immune system, while IL-17E boosts the Th2 immune system. The IL-17R receptor also activates the NF-kappa B and C/EBP pathways.

T cells from the immune system recognize this epitope and trigger powerful responses. CD8+ T cells recognize this epitope in the midst of their primary affector response. This can reach 11%. Researchers can also observe the level of immunodominant cell activation and deactivation to determine if the patient has any prior immunity against the YF-17D vector.

IL-17B

The IL-17B marker is part of the Picoband(tm) line of antibodies made by Boster Bio. The anti-IL-17 antibody is able to react with Human, Mouse, and Rat cytokines. It can be tested using multiple platforms, including IHC and ELISA. Its sensitivity and specificity have been validated in multiple biological assays. In addition to ELISA and IHC, Boster Bio rewards scientists who are among the first to review its products with product credits. This incentive has made scientists from all over the world excited about this marker.

The IL-17A gene encodes Interleukin-17A, the cytokine which activated T cells produce. It regulates the activities of NF-kappaB and mitogen-activated protein kinases (MAPKs). It also increases IL6 (and nitric oxygen) expressions which are key cytokines in multiple sclerosis and psoriasis. This antibody from Boster Bio has been tested for specificity and affinity, and can also be used to observe the activity of IL-17B in various clinical contexts.

Many applications can be made from the IL-17B marker. In addition to determining the effectiveness of treatments for various inflammation-related diseases, it has been found to be useful in identifying the nature of a b cell. A single immunogen can cause multiple GCs in a single patient. The use of IL-17B to diagnose a disease is particularly helpful in identifying the one that has the highest reactivity or sensitivity.

IL-17D

The IL-17D marker is among the most commonly used antibodies. It has been validated by Boster Bio in both ELISA and immunohistochemistry. This antibody reacts with human, mouse and rat samples. In addition to its specificity and affinity, it also has a wide range of applications. Like all Boster antibodies, its use is based on a variety of biological samples.

The antigen titres in this study varied from one to 20 thousand. The vaccines were tested from at intervals of 9 to 40 days after vaccination. Researchers concluded that neutralizing antibodies are the predominant immune system responsible for the protective effects of YF-17D vaccines. Animal studies have proven that anti-viral treatments can contain neutralizing antibodies. Additionally, immune reactions are controlled by the existing immunity to the YF-17D vector.

IL-17E

The IL-17C protein has many applications that include the study of skin inflammation. Researchers were able to identify the role of this protein in inflammation by using human skin samples, Keratinocytes that were cultured in primary Keratinocytes, mice as models for disease and primary keratinocytes that were cultured. This context shows that IL-17C plays a role in the atopic dermatitis. Boster has created a series of monoclonal antibodies to this marker.

IL-17F

The IL-17C gene encodes interleukin-17, an enzyme encoded by a gene called IL-17C. The cells that produce interleukin-17 protein that regulates the activity of NFKappaB and mitogen-activated protein kinases. Interleukin-17A is linked to chronic inflammation, such as Psoriasis and MS. Boster Bio offers several antibody preparations with this marker, including ELISA, IHC, and immunohistochemistry.

The IL-17 receptor is a receptor that binds to IL-17, triggering the NF-kappa B and TRAF6 pathways. Five members of the IL-17 receptor family share the same gene structure. The IL-17 receptor subunit consists of two extracellular fibronectin-related domains as well as an EF/IL-17 TIR-like cytoplasmic domain. The members of the IL-17 receptor family are vital in the host's defense against autoimmune and extracellular diseases.

This epitope that is immunodominant was recognized by T cells that are CD8+ in high percentages. This epitope could be used to track the process of deactivation and kinetics of T-cell activation. Researchers will be able to use future studies to test the epitope directly and its factors. If this proves true, further research needs to be conducted.

The findings of the study suggest that pre-existing immunity to YF-17D can inhibit the immune response to YF-17D vaccine. Even though the vaccine increases the number of memory CD8+ T cells that generate neutralizing antibodies, the result of YF-17D vaccine is contingent on the degree of existing immunity. However, using this vaccine as a primary vaccination is the most efficient method of utilizing the vaccine supplies.