AND JUN ELISA kits, Transcription factor AP-1 Proteins
Many biological assays use antibodies to detect Transcription factor AP-1, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with Transcription factor AP-1 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop Transcription factor AP-1 antibodies...
We validate the specificity of these antibodies to Transcription factor AP-1 by testing them on tissues known to express JUN positively and negatively. Browse below to find the JUN antibody that suites your experiment. We have 97 of these antibodies and many publications and validation images.
If you cannot find antibodies that fit your needs, contact us for making custom antibodies. We have a full suite of custom antibody services covering from research to diagnostic and therapeutic applications.
Designing a Western blot for Transcription factor AP-1?
The guide has the expected band size, antibodies backed by real blot images, the controls to run alongside, and protocols taken from published papers.
Transcription factor that recognizes and binds to the enhancer heptamer motif 5'-TGA[CG]TCA-3'. Promotes action of NR5A1 when phosphorylated by HIPK3 leading to increased steroidogenic gene expression upon cAMP signaling pathway stimulation.
Involved in activated KRAS-mediated transcriptional activation of USP28 in colorectal cancer (CRC) cells (PubMed:24623306). Binds to the USP28 promoter in colorectal cancer (CRC) cells (PubMed:24623306).
Gene Information
Human
Gene Name:
JUN
Uniprot:
P05412
Entrez:
3725
Family
Belongs to:
bZIP family
Alternative Names
Activator protein 1; AP1; AP-1; cJun; c-Jun; enhancer-binding protein AP1; Jun activation domain binding protein; jun oncogene; jun proto-oncogene; JUN; Proto-oncogene c-Jun; transcription factor AP-1; V-jun avian sarcoma virus 17 oncogene homologp39; v-jun sarcoma virus 17 oncogene homolog (avian); v-jun sarcoma virus 17 oncogene homolog
Molecular Weight
Mass (kDA): 35.676 kDA
Genomic Context
Human
Location:
1p32.1
Sequence:
1; NC_000001.11 (58780791..58784047, complement)
Subcellular Localizations
Nucleus.
Diseases
Neoplasms
Malignant Neoplasms
Cell Transformation, Neoplastic
Carcinoma
Inflammation
Malignant Paraganglionic Neoplasm
Leukemia
Hiv Infections
Mammary Neoplasms
Malignant Neoplasm Of Breast
Infective Disorder
Immunologic Deficiency Syndromes
Neoplasm Metastasis
Liver Carcinoma
Carcinogenesis
Nervousness
Acquired Immunodeficiency Syndrome
Hyperplasia
Tissue Adhesions
Metaplastic Cell Transformation
Interacting Proteins
APLP2
APP
ATF1
ATF2
ATF3
ATF4
ATF7
BATF
BATF3
BBS7
CITED1
CREB3
ETS1
FOS
FOSL1
FOSL2
GOPC
HSP90AA1
HSPA8
KPNA2
MAPK10
MAPK8
MAPRE3
Maz
MDM2
MTA1
NEFM
NFATC1
PRRC2A
SMAD2
STRN4
TCL1A
TUBA1A
TUBB
VRK1
Pathways
Cell Proliferation
Cell Death
Cell Cycle
Cell Growth
Localization
Secretion
Pathogenesis
Regeneration
Cell Differentiation
Translation
Immune Response
Programmed Cell Death
Cell Activation
Oncogenesis
Dna Repair
Induction Of Apoptosis
Inflammatory Response
Transport
Regulation Of Gene Expression
Angiogenesis
PTMs
Phosphorylation
Cleavage
Dephosphorylation
Ubiquitination
Reduction
Oxidation
Methylation
Acetylation
Phosphorothioation
Sumoylation
Biotinylation
Glycosylation
Farnesylation
Deacetylation
Geranylgeranylation
Myristoylation
Sulphation
Demethylation
Ribosylation
Deamidation
Research Areas
Apoptosis
Cancer
Cell Cycle and Replication
Hypoxia
Immunology
Innate Immunity
Signal Transduction
Transcription Factors and Regulators
Tumor Suppressors
Wnt Signaling Pathway
For details, visit: bosterbio.com/bosterbio-gene-info-cards/JUN
References
PMID: 3194415 by Hattori K., et al. Structure and chromosomal localization of the functional intronless human JUN protooncogene.
PMID: 2825349 by Bohmann D., et al. Human proto-oncogene c-jun encodes a DNA binding protein with structural and functional properties of transcription factor AP-1.