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- Table of Contents
Facts about Histone acetyltransferase KAT2A.
Association with the 2-oxoglutarate dehydrogenase complex, which provides succinyl-CoA, is required for histone succinylation (PubMed:29211711). In various complexes, functions either as an acetyltransferase (HAT) or as a succinyltransferase: at the SAGA and ATAC complexes, functions as a histone acetyltransferase (PubMed:17301242, PubMed:19103755, PubMed:29211711).
| Human | |
|---|---|
| Gene Name: | KAT2A |
| Uniprot: | Q92830 |
| Entrez: | 2648 |

| Belongs to: |
|---|
| acetyltransferase family |

EC 2.3.1.48; GCN5 general control of amino-acid synthesis 5-like 2 (yeast); GCN5L2GCN5 (general control of amino-acid synthesis, yeast, homolog)-like 2; GCN5MGC102791; General control of amino acid synthesis protein 5-like 2; General control of amino acid synthesis, yeast, homolog-like 2; hGCN5; Histone acetyltransferase GCN5; histone acetyltransferase KAT2A; hsGCN5; K(lysine) acetyltransferase 2A; Lysine acetyltransferase 2A; PCAF-b; STAF97
Mass (kDA):
93.926 kDA

| Human | |
|---|---|
| Location: | 17q21.2 |
| Sequence: | 17; NC_000017.11 (42113111..42121367, complement) |
Expressed in all tissues tested, with most abundant expression in ovary.
Nucleus. Chromosome. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Mainly localizes to the nucleus (PubMed:27796307). Also localizes to centrosomes in late G1 and around the G1/S transition, coinciding with the onset of centriole formation (PubMed:27796307).





PMID: 8552087 by Candau R., et al. Identification of human proteins functionally conserved with the yeast putative adaptors ADA2 and GCN5.
PMID: 9611240 by Smith E.R., et al. Cloning of Drosophila GCN5: conserved features among metazoan GCN5 family members.