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KAT2A Antibodies
AND KAT2A ELISA kits, KAT2A Proteins
Many biological assays use antibodies to detect KAT2A, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with KAT2A in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop KAT2A antibodies...
Designing a Western blot for KAT2A? The guide has the expected band size, antibodies backed by real blot images, the controls to run alongside, and protocols taken from published papers.
Open the KAT2A Western Blot GuideKAT2A Infographic by Boster Bio
All KAT2A Products
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KAT2A Overview
Facts about Histone acetyltransferase KAT2A.
Histone acetyltransferase KAT2A (KAT2A)
Protein lysine acyltransferase that could act both as a acetyltransferase and succinyltransferase, depending on the context (PubMed:29211711). Succinylation of histones gives a specific tag for epigenetic transcription activation (PubMed:29211711).
Association with the 2-oxoglutarate dehydrogenase complex, which provides succinyl-CoA, is required for histone succinylation (PubMed:29211711). In various complexes, functions either as an acetyltransferase (HAT) or as a succinyltransferase: at the SAGA and ATAC complexes, functions as a histone acetyltransferase (PubMed:17301242, PubMed:19103755, PubMed:29211711).
Gene Information
| Human | |
|---|---|
| Gene Name: | KAT2A |
| Uniprot: | Q92830 |
| Entrez: | 2648 |
Family
| Belongs to: |
|---|
| acetyltransferase family |
Alternative Names
EC 2.3.1.48; GCN5 general control of amino-acid synthesis 5-like 2 (yeast); GCN5L2GCN5 (general control of amino-acid synthesis, yeast, homolog)-like 2; GCN5MGC102791; General control of amino acid synthesis protein 5-like 2; General control of amino acid synthesis, yeast, homolog-like 2; hGCN5; Histone acetyltransferase GCN5; histone acetyltransferase KAT2A; hsGCN5; K(lysine) acetyltransferase 2A; Lysine acetyltransferase 2A; PCAF-b; STAF97
Molecular Weight
Mass (kDA):
93.926 kDA
Genomic Context
| Human | |
|---|---|
| Location: | 17q21.2 |
| Sequence: | 17; NC_000017.11 (42113111..42121367, complement) |
Tissue Specificity
Expressed in all tissues tested, with most abundant expression in ovary.
Subcellular Localizations
Nucleus. Chromosome. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Mainly localizes to the nucleus (PubMed:27796307). Also localizes to centrosomes in late G1 and around the G1/S transition, coinciding with the onset of centriole formation (PubMed:27796307).
Diseases
- Malignant Neoplasms
- Metabolic Diseases
- Metaplastic Cell Transformation
- Malignant Neoplasm Of Breast
- Ataxia
- Neoplasms
- Spinocerebellar Ataxia Type 7
- Cell Transformation, Neoplastic
- Diabetes Mellitus
- Virus Diseases
- Diabetes Mellitus, Non-insulin-dependent
- Ataxia, Spinocerebellar
- Cystic Fibrosis
Interacting Proteins
- AATF
- E2F1
- WDHD1
- ZZZ3
Pathways
- Histone Acetylation
- Cell Cycle
- Gluconeogenesis
- Cell Proliferation
- Cell Growth
- Rna Interference
- Transport
- Histone Deacetylation
- Cellular Homeostasis
- Aging
- Response To Virus
- Regulation Of Gene Expression
- Energy Homeostasis
PTMs
- Acetylation
- Phosphorylation
For details, visit:
bosterbio.com/bosterbio-gene-info-cards/KAT2A
bosterbio.com/bosterbio-gene-info-cards/KAT2A
References
PMID: 8552087 by Candau R., et al. Identification of human proteins functionally conserved with the yeast putative adaptors ADA2 and GCN5.
PMID: 9611240 by Smith E.R., et al. Cloning of Drosophila GCN5: conserved features among metazoan GCN5 family members.