Histone acetyltransferase KAT2B (KAT2B)

Has significant histone acetyltransferase activity with core histones (H3 and H4), and also with nucleosome core particles. Also acetylates non-histone proteins, such as ACLY, PLK4 and TBX5.

Inhibits cell-cycle progression and counteracts the mitogenic action of the adenoviral oncoprotein E1A. Acts as a circadian transcriptional coactivator which enhances the action of the circadian transcriptional activators: NPAS2-ARNTL/BMAL1 and CLOCK- ARNTL/BMAL1 heterodimers.