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- Table of Contents
KAT2B Antibodies
AND KAT2B ELISA kits, KAT2B Proteins
Many biological assays use antibodies to detect KAT2B, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with KAT2B in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop KAT2B antibodies...
Designing a Western blot for KAT2B? The guide has the expected band size, antibodies backed by real blot images, the controls to run alongside, and protocols taken from published papers.
Open the KAT2B Western Blot GuideDesigning an IHC experiment for KAT2B? The guide has the expected staining pattern, antigen retrieval and fixation, antibodies backed by real IHC images, the tissue controls to run alongside, and protocols taken from published papers.
Open the KAT2B IHC GuideKAT2B Infographic by Boster Bio
All KAT2B Products
Product
Figures
Specificity
Applications
Price
Human, Mouse, Rat
ELISA
$480
Cat # EKC1421
1 kit, containing one 96-well plate and all necessary reagents
Cat # EKC1421
1 kit, containing one 96-well plate and all necessary reagents
KAT2B Overview
Facts about Histone acetyltransferase KAT2B.
Histone acetyltransferase KAT2B (KAT2B)
Has significant histone acetyltransferase activity with core histones (H3 and H4), and also with nucleosome core particles. Also acetylates non-histone proteins, such as ACLY, PLK4 and TBX5.
Inhibits cell-cycle progression and counteracts the mitogenic action of the adenoviral oncoprotein E1A. Acts as a circadian transcriptional coactivator which enhances the action of the circadian transcriptional activators: NPAS2-ARNTL/BMAL1 and CLOCK- ARNTL/BMAL1 heterodimers.
Gene Information
| Human | |
|---|---|
| Gene Name: | KAT2B |
| Uniprot: | Q92831 |
| Entrez: | 8850 |
Family
| Belongs to: |
|---|
| acetyltransferase family |
Alternative Names
CREBBP-associated factor; EC 2.3.1.48; GCN5; GCN5L; Histone acetylase PCAF; histone acetyltransferase KAT2B; Histone acetyltransferase PCAF; K(lysine) acetyltransferase 2B; KAT2B; Lysine acetyltransferase 2B; P; P/CAFGCN5; P300/CBP-associated factorCAF; PCAF
Molecular Weight
Mass (kDA):
93.013 kDA
Genomic Context
| Human | |
|---|---|
| Location: | 3p24.3 |
| Sequence: | 3; NC_000003.12 (20040407..20154404) |
Tissue Specificity
Ubiquitously expressed but most abundant in heart and skeletal muscle.
Subcellular Localizations
Nucleus. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Cytoplasm. Mainly localizes to the nucleus. Also localizes to centrosomes in late G1 and around the G1/S transition, coinciding with the onset of centriole formation. Subcellular location may vary depending upon cell differentiation state. Cytoplasmic at the very stages of keratinocyte differentiation, becomes nuclear at later differentiation stages. Cytoplasmic in basal epithelial cells (undifferentiated cells) and nuclear in parabasal cells (differentiated cells) (PubMed:20940255).
Diseases
- Malignant Neoplasms
- Neoplasms
- Malignant Neoplasm Of Breast
- Weakness
- Leukemia
- Mammary Neoplasms
- Inflammation
Interacting Proteins
- BUB1B
- Cebpb
- CREBBP
- EHMT2
- EP300
- HIF1A
- KLF2
- SIRT1
- SIRT2
- TAF9
Pathways
- Cell Cycle
- Methylation
- Dna Replication
- Reverse Transcription
- Histone Acetylation
- Regulation Of Gene Expression
PTMs
- Acetylation
Research Areas
- Cell Cycle and Replication
For details, visit:
bosterbio.com/bosterbio-gene-info-cards/KAT2B
bosterbio.com/bosterbio-gene-info-cards/KAT2B
References
PMID: 8684459 by Yang X.-J., et al. A p300/CBP-associated factor that competes with the adenoviral oncoprotein E1A.
PMID: 8945521 by Ogryzko V.V., et al. The transcriptional coactivators p300 and CBP are histone acetyltransferases.