A-kinase anchor protein 4 Antibodies

AND AKAP4 ELISA kits, A-kinase anchor protein 4 Proteins

Many biological assays use antibodies to detect A-kinase anchor protein 4, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with A-kinase anchor protein 4 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop A-kinase anchor protein 4 antibodies...

We validate the specificity of these antibodies to A-kinase anchor protein 4 by testing them on tissues known to express AKAP4 positively and negatively. Browse below to find the AKAP4 antibody that suites your experiment. We have 1 of these antibodies and many publications and validation images.

If you cannot find antibodies that fit your needs, contact us for making custom antibodies. We have a full suite of custom antibody services covering from research to diagnostic and therapeutic applications.

Designing an IHC experiment for A-kinase anchor protein 4? The guide has the expected staining pattern, antigen retrieval and fixation, antibodies backed by real IHC images, the tissue controls to run alongside, and protocols taken from published papers.

Open the AKAP4 IHC Guide

AKAP4 Infographic by Boster Bio

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Anti-A-kinase anchor protein 4 AKAP4 Antibody

Western blot analysis of AKAP4 in human testis tissue lysate with AKAP4 antibody at (A) 1 and (B) 2 μg/ml

Human

ELISA, IF, IHC-P, WB

$481
Cat # A07362
0.1 mg

AKAP4 Overview

Facts about A-kinase anchor protein 4.

AKAP4 3D structure. Source: alphafold

A-kinase anchor protein 4 (AKAP4)

Major structural component of sperm fibrous sheath. Plays a role in sperm motility.

Gene Information

Human
Gene Name:	AKAP4
Uniprot:	Q5JQC9
Entrez:	8852

Family

Belongs to:

AKAP110 family

Alternative Names

A kinase (PRKA) anchor protein 4; AKAP-4; AKAP82AKAP 82; A-kinase anchor protein 4; A-kinase anchor protein 82 kDa; cancer/testis antigen 99; CT99; hAKAP82Fsc1; HIFSC1; Major sperm fibrous sheath protein; p82; PRKA4; protein kinase A anchoring protein 4; Protein kinase A-anchoring protein 4; testis-specific gene HI

Molecular Weight

Mass (kDA):
94.477 kDA

Genomic Context


Human

Location:	Xp11.22
Sequence:	X; NC_000023.11 (50190777..50201007, complement)

Tissue Specificity

Testis specific; only expressed in round spermatids.

Subcellular Localizations

Cell projection, cilium, flagellum. Localizes to the principle piece of the sperm flagellum.

Diseases

Infertility
Male Infertility
Malignant Neoplasms
Neoplasms
Dysplasia
Multiple Myeloma
Azoospermia
Pathologic Neovascularization
Malignant Paraganglionic Neoplasm
Brain Neoplasms
Congenital Absence Of Germinal Epithelium Of Testes
Neoplasm Metastasis

Malignant Neoplasm Of Brain
Glioma
Thymoma
Hypoxia
Partial Deletion Of Y
Single Gene Defect

Pathways

Sperm Motility
Spermatogenesis
Localization
Acrosome Reaction
Translation
Meiosis
Transport
Fertilization
Spermatid Development
Sperm Capacitation
Protein Phosphorylation
Reproductive Process
Regulation Of Signal Transduction

Cytokine Secretion
Male Meiosis
Protein Transport
Cell Cycle
Regulation Of Sperm Motility
Mrna Stabilization
Angiogenesis

PTMs

Phosphorylation

Cleavage

Sulphation

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/AKAP4

References

PMID: 9514854 by Mohapatra B., et al. Molecular cloning of human testis mRNA specifically expressed in haploid germ cells, having structural homology with the A-kinase anchoring proteins.

PMID: 9822690 by Turner R.M.O., et al. An X-linked gene encodes a major human sperm fibrous sheath protein, hAKAP82. Genomic organization, protein kinase A-RII binding, and distribution of the precursor in the sperm tail.