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- Table of Contents
Myocilin Antibodies
AND MYOC ELISA kits, Myocilin Proteins
Many biological assays use antibodies to detect Myocilin, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with Myocilin in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop Myocilin antibodies...
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MYOC Overview
Facts about Myocilin.
Myocilin (MYOC)
Secreted glycoprotein regulating the activation of distinct signaling pathways in adjacent cells to control unique processes including cell adhesion, cell-matrix adhesion, cytoskeleton organization and cell migration. Negatively regulates cell-matrix adhesion and stress fiber assembly through Rho protein signal transduction.
Modulates the organization of actin cytoskeleton by stimulating the formation of stress fibers through interactions with components of Wnt signaling pathways. Promotes cell migration through activation of PTK2 and the downstream phosphatidylinositol 3-kinase signaling.
Gene Information
| Human | |
|---|---|
| Gene Name: | MYOC |
| Uniprot: | Q99972 |
| Entrez: | 4653 |
Family
| Belongs to: |
|---|
| No superfamily |
Alternative Names
GLC1A; GLC1Amyocilin; GPOA; JOAG; JOAG1; MYOC; Myocilin; myocilin, trabecular meshwork inducible glucocorticoid response; TIGR; TIGRmutated trabecular meshwork-induced glucocorticoid response protein; Trabecular meshwork-induced glucocorticoid response protein
Molecular Weight
Mass (kDA):
56.972 kDA
Genomic Context
| Human | |
|---|---|
| Location: | 1q24.3 |
| Sequence: | 1; NC_000001.11 (171635417..171652688, complement) |
Tissue Specificity
Detected in aqueous humor (PubMed:12697062). Detected in the eye (at protein level) (PubMed:11431441). Widely expressed. Highly expressed in various types of muscle, ciliary body, papillary sphincter, skeletal muscle, heart, and bone marrow-derived mesenchymal stem cells. Expressed predominantly in the retina. In normal eyes, found in the inner uveal meshwork region and the anterior portion of the meshwork. In contrast, in many glaucomatous eyes, it is found in more regions of the meshwork and seems to be expressed at higher levels than in normal eyes, regardless of the type or clinical severity of glaucoma. The myocilin 35 kDa fragment is detected in aqueous humor and to a lesser extent in iris and ciliary body.
Subcellular Localizations
Secreted. Golgi apparatus. Cytoplasmic vesicle. Secreted, extracellular space. Secreted, extracellular space, extracellular matrix. Secreted, extracellular exosome. Mitochondrion. Mitochondrion intermembrane space. Mitochondrion inner membrane. Mitochondrion outer membrane. Rough endoplasmic reticulum. Cell projection. Cell projection, cilium. Located preferentially in the ciliary rootlet and basal body of the connecting cilium of photoreceptor cells, and in the rough endoplasmic reticulum (PubMed:9169133). It is only imported to mitochondria in the trabecular meshwork (PubMed:17516541). Local
Diseases
- Glaucoma
- Glaucoma, Open-angle
- Primary Open Angle Glaucoma
- Intraocular Pressure Disorder
- Ocular Hypertension
- Blind Vision
- Hypertensive Disease
- Hydrophthalmos
- Disorder Of The Optic Nerve
- Primary Congenital Glaucoma
- Aqueous Humor Disorders
- Glaucoma Of Childhood
Interacting Proteins
- MYL2
- SPARC
- SPARCL1
Pathways
- Pathogenesis
- Localization
- Secretion
- Cell Death
- Glycosylation
- Rna Interference
- Cell Adhesion
- Proteolysis
- Secretory Pathway
- Protein Folding
- Transport
- Translation
- Phagocytosis
PTMs
- Glycosylation
- Cleavage
- Reduction
For details, visit:
bosterbio.com/bosterbio-gene-info-cards/MYOC
bosterbio.com/bosterbio-gene-info-cards/MYOC
References
PMID: 9280311 by Ortego J., et al. Cloning and characterization of subtracted cDNAs from a human ciliary body library encoding TIGR, a protein involved in juvenile open angle glaucoma with homology to myosin and olfactomedin.
PMID: 9169133 by Kubota R., et al. A novel myosin-like protein (myocilin) expressed in the connecting cilium of the photoreceptor: molecular cloning, tissue expression, and chromosomal mapping.