Myocilin Antibodies

Myocilin (MYOC)

Secreted glycoprotein regulating the activation of distinct signaling pathways in adjacent cells to control unique processes including cell adhesion, cell-matrix adhesion, cytoskeleton organization and cell migration. Negatively regulates cell-matrix adhesion and stress fiber assembly through Rho protein signal transduction.

Modulates the organization of actin cytoskeleton by stimulating the formation of stress fibers through interactions with components of Wnt signaling pathways. Promotes cell migration through activation of PTK2 and the downstream phosphatidylinositol 3-kinase signaling.

Gene Information

Human
Gene Name:	MYOC
Uniprot:	Q99972
Entrez:	4653

Family

Belongs to:
No superfamily

Alternative Names

GLC1A; GLC1Amyocilin; GPOA; JOAG; JOAG1; MYOC; Myocilin; myocilin, trabecular meshwork inducible glucocorticoid response; TIGR; TIGRmutated trabecular meshwork-induced glucocorticoid response protein; Trabecular meshwork-induced glucocorticoid response protein

Molecular Weight

Mass (kDA):
56.972 kDA

Genomic Context

Human
Location:	1q24.3
Sequence:	1; NC_000001.11 (171635417..171652688, complement)

Tissue Specificity

Detected in aqueous humor (PubMed:12697062). Detected in the eye (at protein level) (PubMed:11431441). Widely expressed. Highly expressed in various types of muscle, ciliary body, papillary sphincter, skeletal muscle, heart, and bone marrow-derived mesenchymal stem cells. Expressed predominantly in the retina. In normal eyes, found in the inner uveal meshwork region and the anterior portion of the meshwork. In contrast, in many glaucomatous eyes, it is found in more regions of the meshwork and seems to be expressed at higher levels than in normal eyes, regardless of the type or clinical severity of glaucoma. The myocilin 35 kDa fragment is detected in aqueous humor and to a lesser extent in iris and ciliary body.

Subcellular Localizations

Secreted. Golgi apparatus. Cytoplasmic vesicle. Secreted, extracellular space. Secreted, extracellular space, extracellular matrix. Secreted, extracellular exosome. Mitochondrion. Mitochondrion intermembrane space. Mitochondrion inner membrane. Mitochondrion outer membrane. Rough endoplasmic reticulum. Cell projection. Cell projection, cilium. Located preferentially in the ciliary rootlet and basal body of the connecting cilium of photoreceptor cells, and in the rough endoplasmic reticulum (PubMed:9169133). It is only imported to mitochondria in the trabecular meshwork (PubMed:17516541). Local

Diseases

• Glaucoma
• Glaucoma, Open-angle
• Primary Open Angle Glaucoma
• Intraocular Pressure Disorder
• Ocular Hypertension
• Blind Vision
• Hypertensive Disease
• Hydrophthalmos
• Disorder Of The Optic Nerve
• Primary Congenital Glaucoma
• Aqueous Humor Disorders
• Glaucoma Of Childhood

• Visual Impairment
• Scleral Diseases
• Low Tension Glaucoma
• Myopia
• Exfoliation Syndrome
• Corticosteroid-induced Glaucoma
• Tissue Adhesions

Interacting Proteins

• MYL2
• SPARC
• SPARCL1

Pathways

• Pathogenesis
• Localization
• Secretion
• Cell Death
• Glycosylation
• Rna Interference
• Cell Adhesion
• Proteolysis
• Secretory Pathway
• Protein Folding
• Transport
• Translation
• Phagocytosis

• Cell Cycle
• Pinocytosis
• Cell Growth
• Protein Processing
• Cell Migration
• Gene Silencing
• Pigmentation

PTMs

• Glycosylation
• Cleavage
• Reduction

• Deglycosylation
• Biotinylation
• Methylation

• Ubiquitination

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/MYOC

Best Uses Of The MYOC Marker For Anti-Apoptosis Research

Boster Bio is a company that specializes in researching anti-apoptosis research and the best uses for the MYOC mark. Boster Bio produces monoclonal antibodies against the Apoptosis marker Bax that can detect apoptosis. These antibodies can be used to submit results for different species or applications by Boster scientists, and also to earn product credits. This product is available to scientists worldwide, and all researchers and scientists worldwide can take advantage of its benefits.

Boster Bio: Anti-Bax (Apoptosis Marker) Monoclonal Antibody

The MYOC Marker is one class of integrins that can be found in many cell types. It binds to certain phosphorylated proteins. Using the antibody, scientists can detect the protein and its receptors. This antibody is useful for many applications, including protein characterization, biochemical characterization, as well as research into tumor cells. Boster Bio provides a monoclonal antibody (MAb), with high affinity, for the MYOC marker. This antibody has been validated for use in immunohistochemistry, Western Blotting, and ELISA.