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- Table of Contents
Facts about Neuronal cell adhesion molecule.
Plays a role in mediating cell-cell connections between Schwann cells and axons. Plays a role in the creation and maintenance of the nodes of Ranvier on myelinated axons.
Human | |
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Gene Name: | NRCAM |
Uniprot: | Q92823 |
Entrez: | 4897 |
Belongs to: |
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immunoglobulin superfamily |
Bravo; hBravo; KIAA0343Neuronal surface protein Bravo; MGC138845; MGC138846; neuronal cell adhesion molecule; NgCAM-related cell adhesion molecule; ng-CAM-related; NrCAM; nr-CAM
Mass (kDA):
143.89 kDA
Human | |
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Location: | 7q31.1 |
Sequence: | 7; NC_000007.14 (108147626..108456720, complement) |
Detected in all the examined tissues. In the brain it was detected in the amygdala, caudate nucleus, corpus callosum, hippocampus, hypothalamus, substantia nigra, subthalamic nucleus and thalamus.
Cell membrane; Single-pass type I membrane protein. Cell projection, axon. Secreted. Detected at nodes of Ranvier.
PMID: 8812479 by Lane R.P., et al. Characterization of a highly conserved human homolog to the chicken neural cell surface protein Bravo/Nr-CAM that maps to chromosome band 7q31.
PMID: 11483367 by Dry K., et al. The complete sequence of the human locus for NgCAM-related cell adhesion molecule reveals a novel alternative exon in chick and man and conserved genomic organization for the L1 subfamily.