PIK3CB Antibodies

Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform (PIK3CB)

Phosphoinositide-3-kinase (PI3K) that phosphorylates PtdIns (Phosphatidylinositol), PtdIns4P (Phosphatidylinositol 4- phosphate) and PtdIns(4,5)P2 (Phosphatidylinositol 4,5- bisphosphate) to generate phosphatidylinositol 3,4,5-trisphosphate (PIP3). PIP3 plays a key role by recruiting PH domain-containing proteins to the membrane, including AKT1 and PDPK1, activating signaling cascades involved in cell growth, survival, proliferation, motility and morphology.

Involved in the activation of AKT1 upon stimulation by G-protein coupled receptors (GPCRs) ligands like CXCL12, sphingosine 1-phosphate, and lysophosphatidic acid. Required in different signaling pathways for stable platelet adhesion and aggregation.

Gene Information

Human
Gene Name:	PIK3CB
Uniprot:	P42338
Entrez:	5291

Family

Belongs to:
PI3/PI4-kinase family

Alternative Names

P110BETA; PI 3Kinase p110 beta; PI 3-Kinase p110 beta; PI3K; PI3KBETA; PIK3C1; PIK3CB phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit beta; PIK3CB

Molecular Weight

Mass (kDA):
122.762 kDA

Genomic Context

Human
Location:	3q22.3
Sequence:	3; NC_000003.12 (138652698..138834928, complement)

Tissue Specificity

Expressed ubiquitously.

Subcellular Localizations

Cytoplasm. Nucleus. Interaction with PIK3R2 is required for nuclear localization and export.

Diseases

• Malignant Neoplasms
• Neoplasms
• Cell Transformation, Neoplastic
• Insulin Resistance
• Carcinoma
• Mammary Neoplasms
• Obesity
• Malignant Neoplasm Of Breast
• Malignant Paraganglionic Neoplasm
• Diabetes Mellitus
• Metaplastic Cell Transformation
• Inflammation
• Dysequilibrium Syndrome

• Prostatic Neoplasms
• Tissue Adhesions
• Malignant Glioma
• Glioma
• Myeloid Leukemia
• Leukemia
• Ovarian Neoplasm

Interacting Proteins

• HCK
• PIK3R1
• PIK3R2
• PIK3R3

Pathways

• Cell Proliferation
• Cell Growth
• Cell Cycle
• Platelet Activation
• Platelet Aggregation
• Rna Interference
• Cell Migration
• Cell Cycle Arrest
• Cell Division
• Cell Development
• Localization
• Cytokine Production
• Pathogenesis

• Secretion
• Cell Adhesion
• Cell Activation
• Diapedesis
• Gene Silencing
• T Cell Activation
• Brain Development

PTMs

• Phosphorylation
• Methylation
• Cleavage

• Ribosylation
• Ubiquitination
• Myristoylation

Research Areas

• Apoptosis
• Cancer
• Cell Cycle and Replication
• mTOR Pathway

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/PIK3CB

Best Uses Of The PIK3CB Marker

In this article, we will take a look at the PIK3CB Marker from Steven Boster, as well as the Picokine ELISA platform from Sanbio. We will also go over the various Applications of the PIK3CB Marker. We will also discuss how to use Picokine ELISA Platform to design custom ElISAs.

Boster Bio's Picokine ELISA platform

In 1993, Steven Xia, a famous histologist from the world, established Boster Bio to develop high-affinity antibodies, high-specificity ones and ELISA kits. Since the time, Boster Bio has continued to enhance the products it produces through more than two decades of research. Boster Bio offers a wide portfolio of antibodies, ranging from monoclonal to bispecific all of which have been transparently tested for use in numerous applications, including Flow Cytometry. Team Boster provides reliable customer service and a Boster Quality Guarantee for all its products. The company is expanding its product line each month.

Boster's Picokine ELISA kit line is the result of more than two decades of research. This groundbreaking technology dramatically improves the affinity of the antibodies used to capture and decreases binding that is not specific. The Picokine ELISA kits are highly sensitive and specific, delivering high specificity and picogram-level sensitivity. Picokine ELISA Kits can detect different proteins and antigens, and have been thoroughly tested.

Boster Bio's Picokine ELIISA kit is powered by proprietary blocking and coating technology. This enables them to reach the sensitivity of a picogram with a low background. The kits are tested at 37°C and contain enough reagents to run tests of 96. Picokine ELISA kits are validated to test a variety of samples. They are available through tebubio.

Picokine ELISA uses high-affinity antibodies to determine a specific protein from a crude formulation. The use of high-affinity antibodies in the assay ensures high-quality, reproducible results. The platform has high-quality control systems, including an adequate CV-value to ensure accurate and consistent results. Picokine ELISA is the ideal choice for your next project due to all these advantages.

Applications of PIK3CB Marker

PIK3CB (or p110b) is a transcription factor found in a variety tissues. It is associated with the proliferation of cells and tumor-related expression. In the box-plots below we show the PIK3CB mRNA and protein levels in relation to the signature of the cell cycle score. Similar to the PCNA protein level is related to PIK3CB expression.

The PIK3CB gene encodes a 122762 Da Protein and is found primarily in the kidney and thyroid. It is involved in signaling pathways that involve receptors that are located on the outer layer of cells of the eukaryotic family. It is a component of the activation pathway in neutrophils. Because of alternative splicing, the PIK3CB gene has numerous paralogs.

While its role in prognosis is unknown, research has shown that breast cancer patients who have higher levels of PIK3CB are more likely to survive. Evidence supporting this prognostic significance are further supported by studies suggesting that PIK3R1 lack of expression can trigger activation of PI3K pathway, which could aid in the progression of tumors and their development. But more research must be done to identify whether or not PIK3R1 is associated with favorable outcomes.