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- Table of Contents
PIK3CD Antibodies
AND PIK3CD ELISA kits, PIK3CD Proteins
Many biological assays use antibodies to detect PIK3CD, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with PIK3CD in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop PIK3CD antibodies...
Designing a Western blot for PIK3CD? The guide has the expected band size, antibodies backed by real blot images, the controls to run alongside, and protocols taken from published papers.
Open the PIK3CD Western Blot GuidePIK3CD Infographic by Boster Bio
All PIK3CD Products
Product
Figures
Specificity
Applications
Price
Human, Mouse, Rat
IF, ICC, WB
$370
Cat # M02269
100 μl
Cat # M02269
100 μl
PIK3CD Overview
Facts about Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform.
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform (PIK3CD)
Phosphoinositide-3-kinase (PI3K) that phosphorylates PftdIns(4,5)P2 (Phosphatidylinositol 4,5-bisphosphate) to generate phosphatidylinositol 3,4,5-trisphosphate (PIP3). PIP3 plays an integral role by recruiting PH domain-containing proteins to the membrane, including AKT1 and PDPK1, activating signaling cascades involved in cell growth, survival, proliferation, motility and morphology.
Plays a role in B-cell development, proliferation, migration, and function. Required for B-cell receptor (BCR) signaling.
Gene Information
| Human | |
|---|---|
| Gene Name: | PIK3CD |
| Uniprot: | O00329 |
| Entrez: | 5293 |
Family
| Belongs to: |
|---|
| PI3/PI4-kinase family |
Alternative Names
EC 2.7.1; EC 2.7.1.153; p110D; P110DELTA; Phosphatidylinositol-4,5-bisphosphate 3-kinase 110 kDa catalytic subunit delta; phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta isoform; phosphoinositide-3-kinase C; phosphoinositide-3-kinase, catalytic, delta polypeptide; PI 3Kinase p110 delta; PI 3-Kinase p110 delta; PI3K; PI3K-delta; PI3-kinase p110 subunit delta; PI3-kinase subunit delta; PIK3CD; PtdIns-3-kinase subunit delta; PtdIns-3-kinase subunit p110-delta
Molecular Weight
Mass (kDA):
119.479 kDA
Genomic Context
| Human | |
|---|---|
| Location: | 1p36.22 |
| Sequence: | 1; NC_000001.11 (9629889..9729114) |
Tissue Specificity
Isoform 2 is expressed in normal thymus, lung and spleen tissues, and is detected at low levels in normal lysates from colon and ovarian biopsies, at elevated levels in lysates from colorectal tumors and is abundantly expressed in some ovarian tumors (at protein level). Both isoform 1 and isoform 2 are widely expressed. Isoform 1 is expressed predominantly in leukocytes.
Subcellular Localizations
Cytoplasm.
Diseases
- Inflammation
- Malignant Neoplasms
- Neoplasms
- Leukemia
- Autoimmune Diseases
- Autoimmune Reaction
- Tissue Adhesions
- Arthritis
- Asthma
- Lymphoid Leukemia
- Lymphoma
- Myeloid Leukemia
- Chronic Lymphocytic Leukemia
Interacting Proteins
- HRAS
- PIK3R1
- PIK3R3
Pathways
- Secretion
- Chemotaxis
- Cell Activation
- T Cell Activation
- Cell Proliferation
- Cytokine Secretion
- Cell Cycle
- Immune Response
- Cell Chemotaxis
- Cell Development
- Localization
- Cytokine Production
- Cell Growth
PTMs
- Phosphorylation
- Nitration
Research Areas
- Autophagy
- mTOR Pathway
- Signal Transduction
For details, visit:
bosterbio.com/bosterbio-gene-info-cards/PIK3CD
bosterbio.com/bosterbio-gene-info-cards/PIK3CD
References
PMID: 9113989 by Vanhaesebroeck B.A.M., et al. P110delta, a novel phosphoinositide 3-kinase in leukocytes.
PMID: 9235916 by Chantry D., et al. p110delta, a novel phosphatidylinositol 3-kinase catalytic subunit that associates with p85 and is expressed predominantly in leukocytes.