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- Table of Contents
PRKACB Antibodies
AND PRKACB ELISA kits, PRKACB Proteins
Many biological assays use antibodies to detect PRKACB, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with PRKACB in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop PRKACB antibodies...
Designing a Western blot for PRKACB? The guide has the expected band size, antibodies backed by real blot images, the controls to run alongside, and protocols taken from published papers.
Open the PRKACB Western Blot GuideDesigning an IHC experiment for PRKACB? The guide has the expected staining pattern, antigen retrieval and fixation, antibodies backed by real IHC images, the tissue controls to run alongside, and protocols taken from published papers.
Open the PRKACB IHC GuidePRKACB Infographic by Boster Bio
All PRKACB Products
Product
Figures
Specificity
Applications
Price
Human, Mouse, Rat
IHC, WB
$370
Cat # M00743T197
100 µl/vial
Cat # M00743T197
100 µl/vial
Human, Mouse, Rat
ELISA
$480
Cat # EKC1691
1 kit, containing one 96-well plate and all necessary reagents
Cat # EKC1691
1 kit, containing one 96-well plate and all necessary reagents
PRKACB Overview
Facts about cAMP-dependent protein kinase catalytic subunit beta.
cAMP-dependent protein kinase catalytic subunit beta (PRKACB)
Mediates cAMP-dependent signaling triggered by receptor binding to GPCRs. PKA activation regulates diverse cellular processes such as cell proliferation, the cell cycle, differentiation and regulation of microtubule dynamics, chromatin condensation and decondensation, nuclear envelope disassembly and reassembly, as well as regulation of intracellular transport mechanisms and ion flux.
Regulates the abundance of compartmentalized pools of its regulatory subunits via phosphorylation of PJA2 which binds and ubiquitinates these subunits, leading to their subsequent proteolysis (PubMed:12420224, PubMed:21423175). Phosphorylates GPKOW which modulates its ability to bind RNA (PubMed:21880142).
Gene Information
| Human | |
|---|---|
| Gene Name: | PRKACB |
| Uniprot: | P22694 |
| Entrez: | 5567 |
Family
| Belongs to: |
|---|
| protein kinase superfamily |
Alternative Names
cAMP-dependent protein kinase catalytic beta subunit isoform 4ab; cAMP-dependent protein kinase catalytic subunit beta; cAPKbeta; DKFZp781I2452; EC 2.7.11; EC 2.7.11.11; MGC41879; MGC9320; PKA C beta; PKA C-beta; PKACB; PRKACB; protein kinase A catalytic subunit beta; protein kinase, cAMP-dependent, catalytic, beta
Molecular Weight
Mass (kDA):
40.623 kDA
Genomic Context
| Human | |
|---|---|
| Location: | 1p31.1 |
| Sequence: | 1; NC_000001.11 (84077975..84238498) |
Tissue Specificity
Isoform 1 is most abundant in the brain, with low level expression in kidney. Isoform 2 is predominantly expressed in thymus, spleen and kidney. Isoform 3 and isoform 4 are only expressed in the brain.
Subcellular Localizations
Cytoplasm. Cell membrane. Membrane; Lipid-anchor. Nucleus. Translocates into the nucleus (monomeric catalytic subunit). The inactive holoenzyme is found in the cytoplasm.
Diseases
- Malignant Neoplasms
- Neoplasms
- Cell Transformation, Neoplastic
- Carcinoma
- Stomach Neoplasms
- Malignant Neoplasm Of Breast
- Polyps
- Malignant Tumor Of Colon
- Glioma
- Lung Diseases
- Myxoid Degeneration
- Melancholic Depression
Interacting Proteins
- APPBP2
- GPKOW
- HSP90AB1
Pathways
- Pathogenesis
- Localization
- Methylation
- Hyperphosphorylation
- Reverse Transcription
- Translation
- Tube Formation
- Fibroblast Proliferation
- Chromatin Organization
PTMs
- Phosphorylation
Research Areas
- Protein Kinase
- Signal Transduction
- Wnt Signaling Pathway
For details, visit:
bosterbio.com/bosterbio-gene-info-cards/PRKACB
bosterbio.com/bosterbio-gene-info-cards/PRKACB
References
PMID: 2342480 by Beebe S.J., et al. Molecular cloning of a tissue-specific protein kinase (C gamma) from human testis -- representing a third isoform for the catalytic subunit of cAMP-dependent protein kinase.
PMID: 11589697 by Orstavik S., et al. Identification of novel splice variants of the human catalytic subunit Cbeta of cAMP-dependent protein kinase.