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RNF138 Antibodies
AND RNF138 ELISA kits, RNF138 Proteins
Many biological assays use antibodies to detect RNF138, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with RNF138 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop RNF138 antibodies...
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RNF138 Overview
Facts about E3 ubiquitin-protein ligase RNF138.
E3 ubiquitin-protein ligase RNF138 (RNF138)
E3 ubiquitin-protein ligase involved in DNA damage response by boosting DNA resection and homologous recombination (PubMed:26502055, PubMed:26502057). Recruited to sites of double- strand breaks after DNA damage and especially promotes double-strand break repair via homologous recombination (PubMed:26502055, PubMed:26502057).
Two distinct, non-exclusive, mechanisms have been proposed. According to a report, regulates the option of double-strand fracture repair by favoring homologous recombination over non-homologous end joining (NHEJ): acts by mediating ubiquitination of XRCC5/Ku80, leading to eliminate the Ku complex from DNA breaks, thereby promoting homologous recombination (PubMed:26502055).
Gene Information
| Human | |
|---|---|
| Gene Name: | RNF138 |
| Uniprot: | Q8WVD3 |
| Entrez: | 51444 |
Family
| Belongs to: |
|---|
| No superfamily |
Alternative Names
E3 ubiquitin-protein ligase RNF138; EC 6.3.2.-; hNARF; HSD-4; MGC8758; NARF; Nemo-like kinase-associated RING finger protein; ring finger protein 138NLK-associated RING finger protein; STRIN
Molecular Weight
Mass (kDA):
28.193 kDA
Genomic Context
| Human | |
|---|---|
| Location: | 18q12.1 |
| Sequence: | 18; NC_000018.10 (32091858..32131561) |
Subcellular Localizations
Chromosome. Recruited at DNA damage sites (PubMed:26502055). Localizes to sites of double-strand break: localization to double-strand break sites is mediated by the zinc fingers (PubMed:26502055, PubMed:26502057).
Diseases
- Cell Transformation, Neoplastic
- Neoplasms
- Stenosis
- Tumor Progression
- Glioma
- Primary Malignant Neoplasm Of Brain
- Malignant Paraganglionic Neoplasm
- Brain Neoplasms
- Carcinogenesis
- Parkinson Disease
- Prolymphocytic Leukemia
Interacting Proteins
- UBE2K
Pathways
- Cell Death
- Pathogenesis
- Neuroprotection
- Cytokine Production
- Cell Proliferation
- Cell Cycle
- Proteolysis
PTMs
- Cleavage
Research Areas
- Zinc Finger
For details, visit:
bosterbio.com/bosterbio-gene-info-cards/RNF138
bosterbio.com/bosterbio-gene-info-cards/RNF138
References
PMID: 16714285 by Yamada M., et al. NARF, an nemo-like kinase (NLK)-associated ring finger protein regulates the ubiquitylation and degradation of T cell factor/lymphoid enhancer factor (TCF/LEF).
PMID: 26502055 by Ismail I.H., et al. The RNF138 E3 ligase displaces Ku to promote DNA end resection and regulate DNA repair pathway choice.