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- Table of Contents
Facts about E3 ubiquitin-protein ligase RNF43.
Acts as a tumor suppressor in the intestinal stem cell zone by inhibiting the Wnt signaling pathway, thereby resticting the size of the intestinal stem cell zone. .
Human | |
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Gene Name: | RNF43 |
Uniprot: | Q68DV7 |
Entrez: | 54894 |
Belongs to: |
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ZNRF3 family |
E3 ubiquitin-protein ligase RNF43
Mass (kDA):
85.722 kDA
Human | |
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Location: | 17q22 |
Sequence: | 17; NC_000017.11 (58352500..58418894, complement) |
Expressed in fetal kidney, fetal lung, in colon cancer tissues, hepatocellular carcinomas and lung adenocarcinomas. Overexpressed in colorectal cancer cell lines.
Cell membrane; Single-pass type I membrane protein. Endoplasmic reticulum membrane; Single-pass type I membrane protein. Nucleus envelope. According to a report, may be secreted.
PMID: 15492824 by Yagyu R., et al. A novel oncoprotein RNF43 functions in an autocrine manner in colorectal cancer.
PMID: 15623641 by Uchida N., et al. Ring finger protein 43 as a new target for cancer immunotherapy.