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- Table of Contents
Facts about Sharpin.
Linear ubiquitination mediated by the LUBAC complex interferes with TNF-induced cell death and thereby prevents inflammation. LUBAC is proposed to be recruited into the TNF-R1 signaling complex (TNF-RSC) following polyubiquitination of TNF-RSC parts by BIRC2 and/or BIRC3 and to conjugate linear polyubiquitin into IKBKG and possibly other components contributing to the stability of the complex.
Human | |
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Gene Name: | SHARPIN |
Uniprot: | Q9H0F6 |
Entrez: | 81858 |
Belongs to: |
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No superfamily |
DKFZp434N1923; hSIPL1; SHANK-associated RH domain interactor; Shank-associated RH domain-interacting protein; Shank-interacting protein-like 1; SHARPIN; SIPL1; SIPL1DKFZP434N1923
Mass (kDA):
39.949 kDA
Human | |
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Location: | 8q24.3 |
Sequence: | 8; NC_000008.11 (144098637..144104248, complement) |
Highly expressed in skeletal muscle and placenta and at lower levels in brain, heart, colon without mucosa, thymus, spleen, kidney, liver, small intestine, lung and peripheral blood leukocytes. Up-regulated in various tumor tissues such as kidney, liver, ovary and pancreas tumors.
Cytoplasm, cytosol. Cell junction, synapse. Enriched at synaptic sites in mature neurons where it colocalizes with SHANK1.
PMID: 12753155 by Daigo Y., et al. Novel human and mouse genes encoding a shank-interacting protein and its upregulation in gastric fundus of W/WV mouse.
PMID: 20179993 by Jung J., et al. Newly identified tumor-associated role of human Sharpin.