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- Table of Contents
1 Citations 5 Q&As
Facts about Toll-like receptor 1.
Cooperates with TLR2 to mediate the innate immune response to bacterial lipoproteins or lipopeptides (PubMed:21078852). Types the activation cluster TLR2:TLR1:CD14 in reaction to triacylated lipopeptides, this cluster activates signaling from the cell surface and then is targeted to the Golgi in a lipid-raft dependent pathway (PubMed:16880211).
Human | |
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Gene Name: | TLR1 |
Uniprot: | Q15399 |
Entrez: | 7096 |
Belongs to: |
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Toll-like receptor family |
CD281 antigen; CD281; DKFZp547I0610; DKFZp564I0682; KIAA0012MGC126311; MGC104956; MGC126312; rsc786; TIL; TIL. LPRS5; TLR1; Toll/interleukin-1 receptor-like protein; toll-like receptor 1
Mass (kDA):
90.291 kDA
Human | |
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Location: | 4p14 |
Sequence: | 4; NC_000004.12 (38791055..38806262, complement) |
Ubiquitous. Highly expressed in spleen, ovary, peripheral blood leukocytes, thymus and small intestine.
Cell membrane; Single-pass type I membrane protein. Cytoplasmic vesicle, phagosome membrane; Single-pass type I membrane protein. Membrane raft. Golgi apparatus. Does not reside in lipid rafts before stimulation but accumulates increasingly in the raft upon the presence of the microbial ligand. In response to triacylated lipoproteins, TLR2:TLR1 heterodimers are recruited in lipid rafts, this recruitment determine the intracellular targeting to the Golgi apparatus.
PMID: 9435236 by Rock F.L., et al. A family of human receptors structurally related to Drosophila Toll.
PMID: 18810425 by Nakajima T., et al. Natural selection in the TLR-related genes in the course of primate evolution.
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