Toll-like receptor 1 (TLR1)

Participates in the innate immune response to microbial agents. Specifically recognizes diacylated and triacylated lipopeptides.

Cooperates with TLR2 to mediate the innate immune response to bacterial lipoproteins or lipopeptides (PubMed:21078852). Types the activation cluster TLR2:TLR1:CD14 in reaction to triacylated lipopeptides, this cluster activates signaling from the cell surface and then is targeted to the Golgi in a lipid-raft dependent pathway (PubMed:16880211).