- Table of Content
Cooperates with TLR2 to mediate the innate immune response to bacterial lipoproteins or lipopeptides (PubMed:21078852). Types the activation cluster TLR2:TLR1:CD14 in reaction to triacylated lipopeptides, this cluster activates signaling from the cell surface and then is targeted to the Golgi in a lipid-raft dependent pathway (PubMed:16880211).
|Toll-like receptor family|
|Sequence:||4; NC_000004.12 (38791055..38806262, complement)|
Ubiquitous. Highly expressed in spleen, ovary, peripheral blood leukocytes, thymus and small intestine.
Cell membrane; Single-pass type I membrane protein. Cytoplasmic vesicle, phagosome membrane; Single-pass type I membrane protein. Membrane raft. Golgi apparatus. Does not reside in lipid rafts before stimulation but accumulates increasingly in the raft upon the presence of the microbial ligand. In response to triacylated lipoproteins, TLR2:TLR1 heterodimers are recruited in lipid rafts, this recruitment determine the intracellular targeting to the Golgi apparatus.
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