YES1 Antibodies

Tyrosine-protein kinase Yes (YES1)

Non-receptor protein tyrosine kinase that is involved in the regulation of cell growth and survival, apoptosis, cell-cell adhesion, cytoskeleton remodeling, and differentiation. Stimulation by receptor tyrosine kinases (RTKs) including EGRF, PDGFR, CSF1R and FGFR contributes to recruitment of YES1 to the phosphorylated receptor, and activation and phosphorylation of downstream substrates.

Upon EGFR activation, promotes the phosphorylation of PARD3 to prefer epithelial tight junction assembly. Participates in the phosphorylation of specific junctional components such as CTNND1 by stimulating the FYN and FER tyrosine kinases in cell-cell contacts.

Gene Information

Human
Gene Name:	YES1
Uniprot:	P07947
Entrez:	7525

Family

Belongs to:
protein kinase superfamily

Alternative Names

cellular yes-1 protein; c-yes; EC 2.7.10; EC 2.7.10.2; HsT441; P61-YES; Proto-oncogene c-Yes; proto-oncogene tyrosine-protein kinase Yes; v-yes-1 Yamaguchi sarcoma viral oncogene homolog 1; Yamaguchi sarcoma oncogene; Yes; YES1

Molecular Weight

Mass (kDA):
60.801 kDA

Genomic Context

Human
Location:	18p11.32
Sequence:	18; NC_000018.10 (721588..812846, complement)

Tissue Specificity

Expressed in the epithelial cells of renal proximal tubules and stomach as well as hematopoietic cells in the bone marrow and spleen in the fetal tissues. In adult, expressed in epithelial cells of the renal proximal tubules and present in keratinocytes in the basal epidermal layer of epidermis.

Subcellular Localizations

Cell membrane. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Cytoplasm, cytosol. Newly synthesized protein initially accumulates in the Golgi region and traffics to the plasma membrane through the exocytic pathway.

Diseases

• Neoplasms
• Malignant Neoplasms
• Tissue Adhesions
• Carcinoma
• Cell Transformation, Neoplastic
• Malignant Paraganglionic Neoplasm
• Malignant Neoplasm Of Breast
• Neoplasm Metastasis
• Cell Invasion
• Mammary Neoplasms
• Malignant Squamous Cell Neoplasm
• Melanoma

• Lymphoma
• Adenocarcinoma
• Liver Carcinoma
• Malignant Tumor Of Colon
• Neoplasm Invasiveness
• Leukemia
• Tumor Angiogenesis

Interacting Proteins

• ALOX5
• AR
• C1orf94
• CDC37
• CDCP1

• EGFR
• FUNDC1
• FXR2
• GAB1
• KIT

• MED28
• MET
• NIF3L1
• OLIG1
• SOCS3

• SSBP3
• THAP1
• TRAF2
• TRAF6
• ZBTB8A

Pathways

• Cell Cycle
• Localization
• Cell Migration
• Cell Motility
• Cell Proliferation
• Pathogenesis
• Transport
• Secretory Pathway
• Translation
• Gastrulation
• Mitosis
• Endocytosis
• Drug Resistance

• Cell Death
• Cell Growth
• Angiogenesis
• Rna Interference
• Cell Adhesion
• Spermatogenesis
• Fertilization

PTMs

• Phosphorylation
• Dephosphorylation
• Palmitoylation

• Nitrosylation
• Cleavage
• Glycosylation

• Acylation

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/YES1

Best Uses Of The YES1 Marker ELISA Kit

There are a variety of uses for the YES1 Marker ELISA Kit. If you're interested in using this marker, then read on. We'll go over some of the best uses and applications. This article will help you make the best decision about your ELISA kit. Learn how to utilize the YES1 Marker ELISA Kit to enhance your research.

YES1 Marker

The YES1 gene code for the YES transcription factor is a well-studied biomarker for autoimmune diseases. It is used to detect various forms of cancer. Boster Biologicals produces ELISA kits for biomarkers across a range of areas, such as neurosciences inflammation, development biology and cancer. These kits are extremely sensitive and can detect the biomarker at a picogram level. Boster Bio provides immunological reagents to detect YES1 proteins and mRNA.

YES1 is a tyrosine kinase that is not a receptor protein. It is involved in cell growth, survival and cell-cell adhesion as as differentiation. When activated, YES1 attracts other kinases to phosphorylated receptors that in turn trigger downstream substrates. The YES1 protein promotes tight junction assembly.

YES1 Marker uses

The gene YES1 has numerous applications in biological research. A small-molecule inhibitor for YES1 can stop the proliferation of b–catenin-dependent tumors in animal models and cell lines. These tumors depend on the b-catenin/YAP1-TBX5 fusion complex for. Although the function of the gene is unknown, the small-molecule inhibitor of YES1 slows tumor growth by blocking a process known as the amplification process of the b-catenin.

This gene is also associated with acquired resistance to medications that block EGFR. 136 patients with EGFR mutations in lung adenocarcinomas were identified to have YES1 amplification. These cases progressed despite treatment with EGFR inhibitors. Among these patients, 66 cases of T790M-negative and seven T790M-positive cases were examined. On the other hand, no patients with EGFR mutations were found to have detectable amplification of SRC or FYN.

Applications for YES1 Markers

YES1 Marker is a biomarker in lung cancer that is associated with mRNA expression in tumors. Patients with NSCLC that have high YES1 levels are more likely to be in poor health. Additionally, YES1 gene amplification is associated with persistent EGFR inhibitor resistance in both cell lines. While it isn't clear what the role YES1 plays in the progression of lung cancer it is believed to play a role in the development of tumors.

Studies of function have revealed that YES1 enhances NSCLC carcinogenesis and plays a role in metastasis. In vivo models that have been preclinically tested showed that tumors spread at a faster rate when YES1 is overexpressed in lung cancer cells. The depletion of genes slowed the growth of tumors. These effects were caused by dasatinib, an SFK inhibitor. Additionally that, high YES1 protein expression was associated with a poor prognosis for lung cancer patients.

It is a cellular homolog of the Yamaguchi Sarcoma virus oncogene that has the activity of tyrosine kinase. It is located between the thymidylate Synase gene and chromosomes 18-22. It is possible that it plays a role in the malignant transformation of hepatocytes . It is essential for keeping embryonic stem cells in an undifferentiated state. It is also a biomarker that could be used to identify early-stage Hepatocellular Cancer. The induction of YES1 by chemotherapy can increase cancer cell activity and mobility.

The YES1 gene was cloned at the laboratory. The protein has been identified by cells with mutations that express the gene. In an article published by Science Translational Medicine, it was identified as a candidate gene to be YES1. This gene is a major factor in controlling the expression of a variety of proteins in human tissues. This gene is expressed in many different illnesses including cancer.

YES1 Marker ELISA kit

YES1 Marker ELISA Kits are available for a variety of biological samples. The MBS1607209 kit is one example. It is able to detect the target analytes for YES1 proteins in biological samples. Boster's kit is equipped with an HRP colorimetric detection system and is suitable to use with tissue homogenates, or secretions. Accuracy and reproducibility are assured by quality control tests.