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- Table of Contents
14-3-3 protein beta/alpha Antibodies
AND YWHAB ELISA kits, 14-3-3 protein beta/alpha Proteins
Many biological assays use antibodies to detect 14-3-3 protein beta/alpha, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with 14-3-3 protein beta/alpha in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop 14-3-3 protein beta/alpha antibodies...
Designing a Western blot for 14-3-3 protein beta/alpha? The guide has the expected band size, antibodies backed by real blot images, the controls to run alongside, and protocols taken from published papers.
Open the YWHAB Western Blot GuideYWHAB Infographic by Boster Bio
All YWHAB Products
Product
Figures
Specificity
Applications
Price
Human, Mouse, Rat
Flow Cytometry, IHC, WB
$370
Cat # M02431-1
100 μl
Cat # M02431-1
100 μl
Human, Mouse, Rat
Flow Cytometry, IP, IF, IHC, ICC, WB
$370
Cat # M02431-3
100 μl
Cat # M02431-3
100 μl
YWHAB Overview
Facts about 14-3-3 protein beta/alpha.
14-3-3 protein beta/alpha (YWHAB)
Adapter protein implicated in the regulation of a large spectrum of both general and specialized signaling pathways. Binds to a lot of partners, usually by recognition of a phosphoserine or phosphothreonine motif.
Binding generally results in the modulation of the activity of the binding partner. Negative regulator of osteogenesis.
Gene Information
| Human | |
|---|---|
| Gene Name: | YWHAB |
| Uniprot: | P31946 |
| Entrez: | 7529 |
Family
| Belongs to: |
|---|
| 14-3-3 family |
Alternative Names
14-3-3 alpha; 14-3-3 beta; 14-3-3 protein beta/alpha; brain protein 14-3-3, beta isoform; GW128; HS1; KCIP-1; Protein 1054; Protein kinase C inhibitor protein 1; protein kinase C inhibitor protein-1; tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, alphapolypeptide; tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, betapolypeptide; YWHAA
Molecular Weight
Mass (kDA):
28.082 kDA
Genomic Context
| Human | |
|---|---|
| Location: | 20q13.12 |
| Sequence: | 20; NC_000020.11 (44885705..44908532) |
Subcellular Localizations
Cytoplasm. Melanosome. Identified by mass spectrometry in melanosome fractions from stage I to stage IV.; Vacuole membrane. (Microbial infection) Upon infection with Chlamydia trachomatis, this protein is associated with the pathogen-containing vacuole membrane where it colocalizes with IncG.
Diseases
- Malignant Neoplasms
- Neoplasms
- Creutzfeldt-jakob Disease
- Tissue Adhesions
- Carcinoma
- Malignant Paraganglionic Neoplasm
- Neoplasm Metastasis
- Nervousness
- Glioblastoma
- Asthma
- Colorectal Cancer
- Nerve Degeneration
Interacting Proteins
- BRAF
- CBL
- CBX4
- CDC25A
- CDC25B
- CDC25C
- CDK14
- DACT1
- GAB2
- GEM
Pathways
- Localization
- Cell Cycle
- Cell Adhesion
- Cell Death
- Cell Growth
- Pathogenesis
- Transport
- Cell Migration
- Immune Response
- Phagocytosis
- Regulation Of Cell Adhesion
- Induction Of Apoptosis
- Response To Lipopolysaccharide
PTMs
- Phosphorylation
- Dephosphorylation
For details, visit:
bosterbio.com/bosterbio-gene-info-cards/YWHAB
bosterbio.com/bosterbio-gene-info-cards/YWHAB
References
PMID: 8515476 by Leffers H., et al. Molecular cloning and expression of the transformation sensitive epithelial marker stratifin. A member of a protein family that has been involved in the protein kinase C signalling pathway.
PMID: 23572552 by Greninger A.L., et al. ACBD3 interaction with TBC1 domain 22 protein is differentially affected by enteroviral and kobuviral 3A protein binding.