Anti-AP-1 complex subunit gamma-1 AP1G1 Antibody

Gamma Adaptin antibody

Boster Bio Anti-AP-1 complex subunit gamma-1 AP1G1 Antibody catalog # A12998-1. Tested in ELISA, WB applications. This antibody reacts with Human, Mouse.

Product Info Summary

SKU: A12998-1
Size: 100ul
Reactive Species: Human, Mouse
Host: Rabbit
Application: ELISA, WB

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Product Name

Anti-AP-1 complex subunit gamma-1 AP1G1 Antibody

View all Gamma Adaptin Antibodies

SKU/Catalog Number

A12998-1

Size

100ul

Form

Liquid

Description

Boster Bio Anti-AP-1 complex subunit gamma-1 AP1G1 Antibody catalog # A12998-1. Tested in ELISA, WB applications. This antibody reacts with Human, Mouse.

Storage & Handling

Store at -20°C for one year. For short term storage and frequent use, store at 4°C for up to one month. Avoid repeated freeze-thaw cycles.

Cite This Product

Anti-AP-1 complex subunit gamma-1 AP1G1 Antibody (Boster Biological Technology, Pleasanton CA, USA, Catalog # A12998-1)

Host

Rabbit

Contents

Liquid form in PBS containing 50% glycerol,and 0.02% sodium azide.

Clonality

Polyclonal

Isotype

IgG

Immunogen

Anti-HICE1 was prepared from whole rabbit serum produced by repeated immunizations with a recombinant full length Hice1 protein.

*Blocking peptide can be purchased. Costs vary based on immunogen length. Contact us for pricing.

Reactive Species

A12998-1 is reactive to AP1G1 in Human, Mouse

Applications

A12998-1 is guaranteed for ELISA, WB Boster Guarantee

Observed Molecular Weight

Calculated molecular weight

91.351kDa

Background of Gamma Adaptin

This antibody is suitable for Cancer, Immunology and Nuclear Signaling research. Hice1 contributes to the mitotic spindle assembly, maintenance of centrosome integrity and completion of cytokinesis as part of the HAUS augmin-like complex. Normal bipolar spindle formation is critical for accurate chromosome segregation and proper mitotic progression. Failure in this event leads to spindle checkpoint activation and chromosome missegregation that ultimately leads to aneuploidy. Hice1 binds to microtubules directly, and promotes spindle integrity and chromosome stability. Hice1 has also shown to play an important role in targeting the gamma TuRC complex to the mitotic spindle, a step that appears to be required for spindle-mediated microtubule generation and normal chromosome segregation. The HAUS augmin-like complex's interaction with microtubules is strong during mitosis, while it is weak or absent during interphase. During interphase, it is primarily cytoplasmic, associating with centrosomes and with the mitotic spindles, preferentially at the spindle pole vicinity. During anaphase and telophase, it additionally associates with the spindle midzone and midbody, respectively. Further characterization of the function of Hice1 will likely be important for better understanding the mechanism of normal mitotic progression and high fidelity chromosome segregation.

Antibody Validation

Boster validates all antibodies on WB, IHC, ICC, Immunofluorescence, and ELISA with known positive control and negative samples to ensure specificity and high affinity, including thorough antibody incubations.

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Assay Dilutions Recommendation

The recommendations below provide a starting point for assay optimization. The actual working concentration varies and should be decided by the user.

WB 1:500-2000 ELISA 1:5000-20000

Validation Images & Assay Conditions

There are currently no images for this product. We are working on uploading them please check back shortly or contact us to expedite our upload process for this antibody.

Gene/Protein Information For AP1G1 (Source: Uniprot.org, NCBI)

Gene Name

AP1G1

Full Name

AP-1 complex subunit gamma-1

Weight

91.351kDa

Superfamily

adaptor complexes large subunit family

Alternative Names

Adapter-related protein complex 1 subunit gamma-1; Adaptor protein complex AP-1 subunit gamma-1; adaptor-related protein complex 1, gamma 1 subunit; ADTGclathrin assembly protein complex 1 gamma large chain; AP-1 complex subunit gamma-1; CLAPG1clathrin-associated/assembly/adaptor protein, large, gamma 1; Clathrin assembly protein complex 1 gamma-1 large chain; gamma adaptin; gamma1-adaptin; golgi adaptor HA1/AP1 adaptin gamma subunit; Golgi adaptor HA1/AP1 adaptin subunit gamma-1; MGC18255 AP1G1 ADTG, CLAPG1 adaptor related protein complex 1 subunit gamma 1 AP-1 complex subunit gamma-1|adapter-related protein complex 1 subunit gamma-1|adaptor protein complex AP-1 subunit gamma-1|adaptor related protein complex 1 gamma 1 subunit|clathrin assembly protein complex 1 gamma large chain|clathrin assembly protein complex 1 gamma-1 large chain|clathrin-associated/assembly/adaptor protein, large, gamma 1|gamma adaptin|gamma1-adaptin|golgi adaptor HA1/AP1 adaptin gamma subunit|golgi adaptor HA1/AP1 adaptin subunit gamma-1|testicular tissue protein Li 21

*If product is indicated to react with multiple species, protein info is based on the gene entry specified above in "Species".

For more info on AP1G1, check out the AP1G1 Infographic

AP1G1 infographic

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In this infographic, you will see the following information for AP1G1: database IDs, superfamily, protein function, synonyms, molecular weight, chromosomal locations, tissues of expression, subcellular locations, post-translational modifications, and related diseases, research areas & pathways. If you want to see more information included, or would like to contribute to it and be acknowledged, please contact [email protected].

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Order DetailsPrice
A12998-1-100ul

100ul

$380

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