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Product Info Summary
| SKU: | M06167 |
|---|---|
| Size: | 0.1 mg |
| Reactive Species: | Human |
| Host: | Mouse |
| Application: | IP, ICC, WB |
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Product info
Product Name
Anti-ARAP1 Purified Monoclonal Antibody
SKU/Catalog Number
M06167
Size
0.1 mg
Form
Liquid
Description
Boster Bio Anti-ARAP1 Purified Monoclonal Antibody (Catalog# M06167). Tested in IP, WB, ICC application(s). This antibody reacts with Human.
Storage & Handling
Store at 2-8°C. Do not freeze.
Cite This Product
Anti-ARAP1 Purified Monoclonal Antibody (Boster Biological Technology, Pleasanton CA, USA, Catalog # M06167)
Host
Mouse
Contents
Phosphate buffered saline (PBS), pH 7.4, 15 mM sodium azide
Clonality
Monoclonal
Clone Number
ARAP1-2
Isotype
Mouse IgG1
Immunogen
His6-tagged protein corresponding to amino acids 1190-1450 of human ARAP1. The antibody ARAP1-2 reacts with C-terminal part of ARAP1 (intracellular epitope), a 160 kDa adaptor protein.
*Blocking peptide can be purchased. Costs vary based on immunogen length. Contact us for pricing.
Cross-reactivity
Cross-reactivity with CLIC5b was not determined.
Reactive Species
M06167 is reactive to Arap1 in Human
Applications
M06167 is guaranteed for IP, ICC, WB Boster Guarantee
Observed Molecular Weight
42 kDa
Calculated molecular weight
162.276kDa
Background of Arap1
ARAP1 (angiotensin II type 1 receptor-associated protein) is an adaptor protein with ArfGAP and RhoGAP activities, containing five PH domains and ankyrin repeate. This adaptor seems to serve as a link between phosphoinositide- Arf-, and Rho-mediated cell signaling. ARAP1 supports the plasma membrane recycling of angiotensin II type 1 receptor (AT1) and is important also for cell-specific trafficking of pro-death receptor TRAIL-R1 (DR4) to the plasma membrane, thus promoting the TRAIL-induced apoptosis in certain cell types. ARAP1 also affects cell spreading.
Antibody Validation
Boster validates all antibodies on WB, IHC, ICC, Immunofluorescence, and ELISA with known positive control and negative samples to ensure specificity and high affinity, including thorough antibody incubations.
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Assay dilution & Images
Assay Dilutions Recommendation
The recommendations below provide a starting point for assay optimization. The actual working concentration varies and should be decided by the user.
Western blotting: 2 μg/ml
Validation Images & Assay Conditions
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Figure 1. Immunocytochemistry staining of ARAP1 using Anti-ARAP1 Purified Monoclonal Antibody (M06167).
Immunocytochemistry detection of colocalization of ARAP1 with DR4 at the plasma membrane and in early endosomes. ARAP1-transfected NCTC cells were treated with TRAIL for 0´Protein Target Info & Infographic
Gene/Protein Information For Arap1 (Source: Uniprot.org, NCBI)
Gene Name
Arap1
Full Name
Arf-GAP with Rho-GAP domain, ANK repeat and PH domain-containing protein 1
Weight
162.276kDa
Alternative Names
arf-GAP with Rho-GAP domain, ANK repeat and PH domain-containing protein 1; ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 1; centaurin, delta 2; Centaurin-delta-2; CENTD2ARF-GAP, RHO-GAP, ankyrin repeat, and pleckstrin homology domains-containingprotein 1; cnt-d2; KIAA0782centaurin-delta-2 Arap1|2410002L19Rik, Centd, Centd2, mKIAA0782|ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 1|arf-GAP with Rho-GAP domain, ANK repeat and PH domain-containing protein 1|centaurin, delta 2|cnt-d2
*If product is indicated to react with multiple species, protein info is based on the gene entry specified above in "Species".For more info on Arap1, check out the Arap1 Infographic
We have 30,000+ of these available, one for each gene! Check them out.
In this infographic, you will see the following information for Arap1: database IDs, superfamily, protein function, synonyms, molecular weight, chromosomal locations, tissues of expression, subcellular locations, post-translational modifications, and related diseases, research areas & pathways. If you want to see more information included, or would like to contribute to it and be acknowledged, please contact [email protected].
Specific Publications For Anti-ARAP1 Purified Monoclonal Antibody (M06167)
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No publications found for M06167
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Customer Reviews
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