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Product Info Summary
| SKU: | A01563-1 |
|---|---|
| Size: | 0.1 mg |
| Reactive Species: | Human, Mouse, Rat |
| Host: | Rabbit |
| Application: | ELISA, IF, ICC, WB |
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Product info
Product Name
Anti-ATR ANTXR1 Antibody
View all TEM8/ANTXR1 Antibodies
SKU/Catalog Number
A01563-1
Size
0.1 mg
Form
Liquid
Description
Boster Bio Anti-ATR ANTXR1 Antibody (Catalog # A01563-1). Tested in ELISA, WB, ICC, IF applications. This antibody reacts with Human, Mouse, Rat.
Storage & Handling
ATR antibody can be stored at 4°C for three months and -20°C, stable for up to one year. Avoid repeated freeze-thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Cite This Product
Anti-ATR ANTXR1 Antibody (Boster Biological Technology, Pleasanton CA, USA, Catalog # A01563-1)
Host
Rabbit
Contents
ATR Antibody is supplied in PBS containing 0.02% sodium azide.
Clonality
Polyclonal
Isotype
IgG
Immunogen
ATR antibody was raised against a peptide corresponding to 13 amino acids near the C-terminus of human ATR. The immunogen is located within the last 50 amino acids of ATR.
*Blocking peptide can be purchased. Costs vary based on immunogen length. Contact us for pricing.
Cross-reactivity
ATR antibody will recognize only the largest isoform.
Reactive Species
A01563-1 is reactive to Antxr1 in Human, Mouse, Rat
Applications
A01563-1 is guaranteed for ELISA, IF, ICC, WB Boster Guarantee
Observed Molecular Weight
68 kDa
Calculated molecular weight
62.308kDa
Background of TEM8/ANTXR1
The Anthrax toxin receptor (ATR) was initially discovered as the tumor endothelial marker 8 (TEM8). This protein, which exists in three isoforms (36, 40, and 60 kDa), is highly expressed in tumor vessels as well as in the vasculature of developing embryos, suggesting that it may normally play a role in angiogenesis. However, it also acts as the receptor for anthrax toxin. Following the binding of this protein by the protective antigen (PA) of anthrax, PA is cleaved and heptamerizes to form the binding site for both edema factor (EF) and lethal factor (LF). This complex is then endocytosed by the cell; acidification in endosomes allows the release of EF and LF into the cytoplasm where they interfere with MAPK signaling and induce apoptosis.
Antibody Validation
Boster validates all antibodies on WB, IHC, ICC, Immunofluorescence, and ELISA with known positive control and negative samples to ensure specificity and high affinity, including thorough antibody incubations.
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Assay dilution & Images
Assay Dilutions Recommendation
The recommendations below provide a starting point for assay optimization. The actual working concentration varies and should be decided by the user.
ATR antibody can be used for detection of ATR by Western blot at 0.5 to 2 μg/mL. Antibody can also be used for immunocytochemistry starting at 2 μg/mL. For immunofluorescence start at 10 μg/mL.
Antibody validated: Western Blot in human samples; Immunocytochemistry in human samples and Immunofluorescence in human samples. All other applications and species not yet tested. Optimal dilutions for each application should be determined by the researcher.
Validation Images & Assay Conditions
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Western blot analysis of ATR in K562 cell lysates with ATR antibody at (A) 0.5
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Immunocytochemistry of ATR in K562 cells with ATR antibody at 2 μg/mL.
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Immunofluorescence of ATR in K562 cells with ATR antibody at 10 μg/mL.
Protein Target Info & Infographic
Gene/Protein Information For Antxr1 (Source: Uniprot.org, NCBI)
Gene Name
Antxr1
Full Name
Anthrax toxin receptor 1
Weight
62.308kDa
Superfamily
ATR family
Alternative Names
anthrax toxin receptor 1; ANTXR1; ATR2310008J16Rik; FLJ10601; FLJ11298; FLJ21776; TEM8; TEM82810405N18Rik; Tumor endothelial marker 8 Antxr1|2310008J16Rik, 2810405N18Rik, Antrx1, Tem8|anthrax toxin receptor 1|anthrax toxin receptor 1|tumor endothelial marker 8
*If product is indicated to react with multiple species, protein info is based on the gene entry specified above in "Species".For more info on Antxr1, check out the Antxr1 Infographic
We have 30,000+ of these available, one for each gene! Check them out.
In this infographic, you will see the following information for Antxr1: database IDs, superfamily, protein function, synonyms, molecular weight, chromosomal locations, tissues of expression, subcellular locations, post-translational modifications, and related diseases, research areas & pathways. If you want to see more information included, or would like to contribute to it and be acknowledged, please contact [email protected].
Specific Publications For Anti-ATR ANTXR1 Antibody (A01563-1)
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