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Product Info Summary
| SKU: | A00295 |
|---|---|
| Size: | 0.1 mg |
| Reactive Species: | Human, Mouse, Rat |
| Host: | Rabbit |
| Application: | ELISA, IF, ICC, WB |
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Product info
Product Name
Anti-CXCR3 Antibody
SKU/Catalog Number
A00295
Size
0.1 mg
Form
Liquid
Description
Boster Bio Anti-CXCR3 Antibody (Catalog # A00295). Tested in ELISA, WB, ICC, IF applications. This antibody reacts with Human, Mouse, Rat.
Storage & Handling
CXCR3 antibody can be stored at 4°C for three months and -20°C, stable for up to one year.
Cite This Product
Anti-CXCR3 Antibody (Boster Biological Technology, Pleasanton CA, USA, Catalog # A00295)
Host
Rabbit
Contents
CXCR3 antibody is supplied in PBS containing 0.02% sodium azide.
Clonality
Polyclonal
Isotype
IgG
Immunogen
CXCR3 antibody was raised against a 19 amino acid peptide near the carboxy terminus of human CXCR3 . The immunogen is located within the last 50 amino acids of CXCR3.
Cross-reactivity
CXCR3 antibody is human, mouse and rat reactive. At least two isoforms of CXCR3 are known to exist; this antibody will detect both isoforms.
Reactive Species
A00295 is reactive to CXCR3 in Human, Mouse, Rat
Observed Molecular Weight
68 kDa
Calculated molecular weight
40.7 kDa
Background of CXCR3
The CXCR3 protein is a G protein-coupled receptor with selectivity for three chemokines, termed CXCL9/Mig (monokine induced by interferon-gamma), CXCL10/IP10 (interferon-gamma-inducible 10 kDa protein) and CXCL11/I-TAC (interferon-inducible T cell alpha-chemoattractant) (reviewed in 1). Binding of chemokines to this protein induces cellular responses that are involved in leukocyte traffic, most notably integrin activation, cytoskeletal changes and chemotactic migration (2). Similar to other chemokine receptors such as CXCR4, CXCR3 has been implicated in several malignancies as a biomarker of tumor behavior as well as a potential therapeutic target (3).
Antibody Validation
Boster validates all antibodies on WB, IHC, ICC, Immunofluorescence, and ELISA with known positive control and negative samples to ensure specificity and high affinity, including thorough antibody incubations.
Application & Images
Applications
A00295 is guaranteed for ELISA, IF, ICC, WB Boster Guarantee
Assay Dilutions Recommendation
The recommendations below provide a starting point for assay optimization. The actual working concentration varies and should be decided by the user.
CXCR3 antibody can be used for detection of CXCR3 by Western blot at 1 - 2 μg/ml. Antibody can also be used for Immunocytochemistry at 5 μg/mL. For Immunoflorescence start at 20 μg/mL.
Antibody validated: Western Blot in human samples; Immunocytochemistry in human samples and Immunofluorescence in human samples. All other applications and species not yet tested. Optimal dilutions for each application should be determined by the researcher.
Validation Images & Assay Conditions
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Western blot analysis of CXCR3 in HepG2 lysate with CXCR3 antibody at (A) 1 and (B) 2 μg/ml.
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Immunocytochemistry of CXCR3 in HepG2 cells with CXCR3 antibody at 5 μg/mL.
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Immunofluorescence of CXCR3 in HepG2 cells with CXCR3 antibody at 20 μg/mL.
Specific Publications For Anti-CXCR3 Antibody (A00295)
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