Anti-Cytokeratin 15 (KRT15) (Basal Cell Marker) Monoclonal Antibody

Product Name

Anti-Cytokeratin 15 (KRT15) (Basal Cell Marker) Monoclonal Antibody

View all Cytokeratin 15 Antibodies

SKU/Catalog Number

M06791

Size

100ug/vial

Form

Liquid

Description

Boster Bio Anti-Cytokeratin 15 (KRT15) (Basal Cell Marker) Monoclonal Antibody (Catalog # M06791). Tested in IHC applications. This antibody reacts with Human, Rat, Cow.

Storage & Handling

Antibody with azide - store at 2 to 8°C. Antibody without azide - store at -20 to -80°C. Antibody is stable for 24 months. Non-hazardous. No MSDS required.

Cite This Product

Anti-Cytokeratin 15 (KRT15) (Basal Cell Marker) Monoclonal Antibody (Boster Biological Technology, Pleasanton CA, USA, Catalog # M06791)

Host

Mouse

Contents

Prepared in 10mM PBS with 0.05% BSA & 0.05% azide. Also available WITHOUT BSA & azide at 1.0mg/ml.

Clonality

Monoclonal

Clone Number

Clone: KRT15/1699

Isotype

IgG2a, kappa

Immunogen

Recombinant human KRT15 protein

*Blocking peptide can be purchased. Costs vary based on immunogen length. Contact us for pricing.

Cross-reactivity

Does not cross-react with primate, avian or amphibian GR.

Reactive Species

M06791 is reactive to KRT15 in Cow, Human, Rat

Applications

M06791 is guaranteed for IHC Boster Guarantee

Observed Molecular Weight

68 kDa

Calculated molecular weight

49.212kDa

Background of Cytokeratin 15

Keratin 15 is a type I keratin which is expressed only in basal keratinocytes in stratified epithelia and does not appear to have a natural type II expression partner. Keratin 15 is down regulated in activated keratinocytes. Cytokeratin 15 is a specific marker of stem cells of the hair-follicle bulge and may be a useful marker for diagnosis between basal cell carcinoma (BCC) and trichoepithelioma. Trichoblastoma are benign neoplasms of follicular differentiation frequently found in nevus sebaceous. Many morphologic features are shared with nodular basal cell carcinoma, sometimes rendering a diagnosis difficult. Trichoblastoma and BCC show variable expression of Cytokeratin 15 and Cytokeratin 19, and absence of hair keratins.

Antibody Validation

Boster validates all antibodies on WB, IHC, ICC, Immunofluorescence, and ELISA with known positive control and negative samples to ensure specificity and high affinity, including thorough antibody incubations.

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Reconsitution

Reconstitute with distilled water.

Assay Dilutions Recommendation

The recommendations below provide a starting point for assay optimization. The actual working concentration varies and should be decided by the user.

Immunohistochemistry (Formalin-fixed) (0.1-0.2ug/ml for 30 min at RT)(Staining of formalin-fixed tissues requires heating tissue sections in 10mM Tris with 1mM EDTA, pH 9.0, for 45 min at 95°C followed by cooling at RT for 20 minutes)
Optimal dilution for a specific application should be determined.

Validation Images & Assay Conditions

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Formalin-fixed, paraffin-embedded human Basal Cell Carcinoma stained with Anti-Cytokeratin 15 Mouse Monoclonal Antibody (KRT15/1699).

Gene/Protein Information For KRT15 (Source: Uniprot.org, NCBI)

Alternative Names

CK15; CK-15; cytokeratin 15; Cytokeratin-15; K15keratin-15, basic; K1CO; keratin 15; keratin, type I cytoskeletal 15; Keratin-15; keratin-15, beta; KRTB; type I cytoskeletal 15 KRT15 CK15, K15, K1CO keratin 15 keratin, type I cytoskeletal 15|CK-15|cytokeratin 15|keratin 15, type I|keratin-15, basic|keratin-15, beta|type I cytoskeletal 15

For more info on KRT15, check out the KRT15 Infographic

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In this infographic, you will see the following information for KRT15: database IDs, superfamily, protein function, synonyms, molecular weight, chromosomal locations, tissues of expression, subcellular locations, post-translational modifications, and related diseases, research areas & pathways. If you want to see more information included, or would like to contribute to it and be acknowledged, please contact [email protected].

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