Anti-Fermitin family homolog 2 FERMT2 Antibody

Product Name

Anti-Fermitin family homolog 2 FERMT2 Antibody

View all MIG2/Kindlin-2 Antibodies

SKU/Catalog Number

A03653

Size

100ul

Form

Liquid

Description

Boster Bio Anti-Fermitin family homolog 2 FERMT2 Antibody catalog # A03653. Tested in WB,IHC applications. This antibody reacts with Human,Mouse,Rat.

Storage & Handling

Store at -20°C for one year. For short term storage and frequent use, store at 4°C for up to one month. Avoid repeated freeze-thaw cycles.

Cite This Product

Anti-Fermitin family homolog 2 FERMT2 Antibody (Boster Biological Technology, Pleasanton CA, USA, Catalog # A03653)

Host

Rabbit

Contents

Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

Clonality

Polyclonal

Isotype

IgG

Immunogen

Synthesized peptide derived from human HoxB4.

*Blocking peptide can be purchased. Costs vary based on immunogen length. Contact us for pricing.

Reactive Species

A03653 is reactive to FERMT2 in Human, Mouse, Rat

Applications

A03653 is guaranteed for IHC, WB Boster Guarantee

Observed Molecular Weight

Calculated molecular weight

77.861kDa

Background of MIG2/Kindlin-2

Pro-apoptopic protein capable of selectively inducing apoptosis in cancer cells, sensitizing the cells to diverse apoptotic stimuli and causing regression of tumors in animal models. Induces apoptosis in certain cancer cells by activation of the Fas prodeath pathway and coparallel inhibition of NF-kappa-B transcriptional activity. Inhibits the transcriptional activation and augments the transcriptional repression mediated by WT1. Down-regulates the anti-apoptotic protein BCL2 via its interaction with WT1. Seems also to be a transcriptional repressor by itself. May be directly involved in regulating the amyloid precursor protein (APP) cleavage activity of BACE1.

Hongzhe Li, J. Biol. Chem., Feb 2007; 282: 4943 - 4950.
Wuhan Xiao, Cancer Res., Aug 2003; 63: 4698 - 4704.
Thierry Virolle, J. Biol. Chem., Mar 2003; 278: 11802 - 11810.
Derek J. Richard, Genes & Dev., Feb 2001; 15: 328.

Antibody Validation

Boster validates all antibodies on WB, IHC, ICC, Immunofluorescence, and ELISA with known positive control and negative samples to ensure specificity and high affinity, including thorough antibody incubations.

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Assay Dilutions Recommendation

The recommendations below provide a starting point for assay optimization. The actual working concentration varies and should be decided by the user.

WB: 1:1000-1:2000
IHC: 1:50-1:200

Validation Images & Assay Conditions

There are currently no images for this product. We are working on uploading them please check back shortly or contact us to expedite our upload process for this antibody.

Gene/Protein Information For FERMT2 (Source: Uniprot.org, NCBI)

Alternative Names

fermitin family homolog 2 (Drosophila); fermitin family homolog 2; fermitin family member 2; FERMT2; KIND2; KIND2DKFZp686G11125; kindlin 2; Kindlin-2; MIG2; mig-2; MIG2FLJ34213; mitogen inducible gene 2 protein; Mitogen-inducible gene 2 protein; PH domain-containing family C member 1; pleckstrin homology domain containing, family C (with FERM domain) member 1; pleckstrin homology domain containing, family C member 1; Pleckstrin homology domain-containing family C member 1; PLEKHC1; PLEKHC1FLJ44462; UNC112; UNC112B FERMT2 KIND2, MIG2, PLEKHC1, UNC112, UNC112B, mig-2 FERM domain containing kindlin 2 fermitin family homolog 2|PH domain-containing family C member 1|fermitin family member 2|kindlin 2|mitogen inducible gene 2 protein|mitogen inducible gene-2|pleckstrin homology domain containing, family C (with FERM domain) member 1|pleckstrin homology domain containing, family C member 1

For more info on FERMT2, check out the FERMT2 Infographic

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In this infographic, you will see the following information for FERMT2: database IDs, superfamily, protein function, synonyms, molecular weight, chromosomal locations, tissues of expression, subcellular locations, post-translational modifications, and related diseases, research areas & pathways. If you want to see more information included, or would like to contribute to it and be acknowledged, please contact [email protected].

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