Anti-Fos B/FOSB Antibody

Product Name

Anti-Fos B/FOSB Antibody

View all FosB/G0S3 Antibodies

SKU/Catalog Number

PA1478

Size

100 μg/vial

Form

Lyophilized

Description

Boster Bio Anti-Fos B/FOSB Antibody catalog # PA1478. Tested in WB applications. This antibody reacts with Human, Mouse, Rat.

Storage & Handling

Store at -20˚C for one year from date of receipt. After reconstitution, at 4˚C for one month. It can also be aliquotted and stored frozen at -20˚C for six months. Avoid repeated freeze-thaw cycles.

Cite This Product

Anti-Fos B/FOSB Antibody (Boster Biological Technology, Pleasanton CA, USA, Catalog # PA1478)

Host

Rabbit

Contents

Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg Thimerosal, 0.05mg NaN3.

Clonality

Polyclonal

Isotype

Rabbit IgG

Immunogen

A synthetic peptide corresponding to a sequence at the N-terminus of human Fos B, identical to the related mouse and rat sequences.

*Blocking peptide can be purchased. Costs vary based on immunogen length. Contact us for pricing.

Cross-reactivity

No cross-reactivity with other proteins

Reactive Species

PA1478 is reactive to FOSB in Human, Mouse, Rat

Applications

PA1478 is guaranteed for WB Boster Guarantee

Observed Molecular Weight

24 kDa

Calculated molecular weight

35.928kDa

Background of FosB/G0S3

FOSB, FBJ murine osteosarcoma viral oncogene homolog B, is a protein that, in humans, is encoded by the FOSB gene. FOSB is a member of Fos gene family which consists of 4 members: FOS, FOSB, FOSL1, and FOSL2. The FOS proteins have been implicated as regulators of cell proliferation, differentiation, and transformation. The FOSB gene is mapped to 19q13.32. Delta FOSB is a truncated splice variant of FOSB. Delta FosB has been implicated in the development of drug addiction and control of the reward system in the brain, and is linked to changes in a number of other gene products such as CREB and sirtuins. Delta FosB also regulates the commitment of mesenchymal precursor cells to the adipocyte or osteoblast lineage.

Antibody Validation

Boster validates all antibodies on WB, IHC, ICC, Immunofluorescence, and ELISA with known positive control and negative samples to ensure specificity and high affinity, including thorough antibody incubations.

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Reconsitution

Add 0.2ml of distilled water will yield a concentration of 500ug/ml.

Assay Dilutions Recommendation

The recommendations below provide a starting point for assay optimization. The actual working concentration varies and should be decided by the user.

Western blot, 0.1-0.5μg/ml, Human, Mouse, Rat

Validation Images & Assay Conditions

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Anti-Fos B antibody, PA1478, Western blotting
Lane 1: HT1080 Cell Lysate
Lane 2: SW620 Cell Lysate
Lane 3: HELA Cell Lysate
Lane 4: SMMC Cell Lysate
Lane 5: MM453 Cell Lysate

Gene/Protein Information For FOSB (Source: Uniprot.org, NCBI)

Alternative Names

activator protein 1; AP-1; DKFZp686C0818; FBJ murine osteosarcoma viral oncogene homolog B; FosB; G0S3; G0S3G0/G1 switch regulatory protein 3; GOS3; GOSB; MGC42291; oncogene FOS-B; protein fosB FOSB AP-1, G0S3, GOS3, GOSB FosB proto-oncogene, AP-1 transcription factor subunit protein fosB|FBJ murine osteosarcoma viral oncogene homolog B|FosB proto-oncogene, AP-1 trancription factor subunit|G0/G1 switch regulatory protein 3|activator protein 1

For more info on FOSB, check out the FOSB Infographic

We have 30,000+ of these available, one for each gene! Check them out.

In this infographic, you will see the following information for FOSB: database IDs, superfamily, protein function, synonyms, molecular weight, chromosomal locations, tissues of expression, subcellular locations, post-translational modifications, and related diseases, research areas & pathways. If you want to see more information included, or would like to contribute to it and be acknowledged, please contact [email protected].

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