Anti-Phospho-GABAB R2 (Ser783) GABBR2 Antibody

Product Name

Anti-Phospho-GABAB R2 (Ser783) GABBR2 Antibody

View all GABBR2 Antibodies

SKU/Catalog Number

P03830

Size

100 µl

Form

Liquid

Description

Boster Bio Anti-Phospho-GABAB R2 (Ser783) GABBR2 Antibody (Catalog # P03830). Tested in WB, IHC, ICC applications. This antibody reacts with Mouse, Rat.

Storage & Handling

Storage at -20°C is recommended, as aliquots may be taken without freeze/thawing due to presence of 50% glycerol. Stable for at least 1 year at -20°C. After date of receipt, stable for at least 1 year at -20°C.

Cite This Product

Anti-Phospho-GABAB R2 (Ser783) GABBR2 Antibody (Boster Biological Technology, Pleasanton CA, USA, Catalog # P03830)

Host

Rabbit

Contents

10 mM HEPES (pH 7.5), 150 mM NaCl, 100 µg per ml BSA and 50% glycerol.

Clonality

Polyclonal

Clone Number

608

Isotype

IgG

Immunogen

Synthetic phospho-peptide corresponding to amino acid residues surrounding Ser783 of the R2 subunit of rat GABAB recerptor, conjugated to keyhole limpet hemocyanin (KLH). Immunogen species is Rat.

*Blocking peptide can be purchased. Costs vary based on immunogen length. Contact us for pricing.

Cross-reactivity

No cross reactivity with other proteins.

Reactive Species

P03830 is reactive to GABBR2 in Mouse, Rat

Applications

P03830 is guaranteed for IHC, ICC, WB Boster Guarantee

Observed Molecular Weight

52 kDa

Calculated molecular weight

105.821kDa

Background of GABBR2

Gamma-aminobutyric acid (GABA) is the primary inhibitory neurotransmitter in the central nervous system. There are two major classes of GABA receptors: the GABA-A and the GABA-B subtype of receptors. GABA-B receptors are heterodimeric G protein-coupled receptors that mediate slow synaptic inhibition in the central nervous system. It has recently been demonstrated that AMPK binds directly to GABA-B receptors and phosphorylates Ser-783 in the cytoplasmic tail of the R2 subunit and that Ser-783 plays a critical role in enhancing neuronal survival after ischemia as phosphorylation of Ser-783 is evident in many brain regions and is increased dramatically after ischemic injury to the brain (Kuramoto et al., 2007).

Antibody Validation

Boster validates all antibodies on WB, IHC, ICC, Immunofluorescence, and ELISA with known positive control and negative samples to ensure specificity and high affinity, including thorough antibody incubations.

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Assay Dilutions Recommendation

The recommendations below provide a starting point for assay optimization. The actual working concentration varies and should be decided by the user.

WB: 1:1000
IHC: 1:500
ICC: 1:500

Validation Images & Assay Conditions

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Western blot of rat synaptic membrane lysate showing specific immunolabeling of the ~102 kDa GABA_B R2 protein phosphorylated at Ser⁷⁸³ in the first lane (-). Phosphospecificity is shown in the second lane (+) where immunolabeling is completely eliminated by blot treatment with lambda phosphatase (gamma-Ptase, 1200 units for 30 min).

Gene/Protein Information For GABBR2 (Source: Uniprot.org, NCBI)

Alternative Names

GABA B Receptor Compounds GABBR2 DEE59, EIEE59, GABABR2, GPR51, GPRC3B, HG20, HRIHFB2099, NDPLHS gamma-aminobutyric acid type B receptor subunit 2 gamma-aminobutyric acid type B receptor subunit 2|G-protein coupled receptor 51|GABA-B receptor 2|GABA-B receptor, R2 subunit|GABA-B-R2|GABA-BR2|gamma-aminobutyric acid (GABA) B receptor, 2|gamma-aminobutyric acid B receptor 2|gb2

For more info on GABBR2, check out the GABBR2 Infographic

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In this infographic, you will see the following information for GABBR2: database IDs, superfamily, protein function, synonyms, molecular weight, chromosomal locations, tissues of expression, subcellular locations, post-translational modifications, and related diseases, research areas & pathways. If you want to see more information included, or would like to contribute to it and be acknowledged, please contact [email protected].

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