Anti-GITRL TNFSF18 Antibody

Product Name

Anti-GITRL TNFSF18 Antibody

View all TNFSF18 Antibodies

SKU/Catalog Number

A04408

Size

0.1 mg

Form

Liquid

Description

Boster Bio Anti-GITRL TNFSF18 Antibody (Catalog # A04408). Tested in ELISA, WB applications. This antibody reacts with Human, Mouse.

Storage & Handling

GITRL antibody can be stored at 4°C for three months and -20°C, stable for up to one year. Avoid repeated freeze-thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Cite This Product

Anti-GITRL TNFSF18 Antibody (Boster Biological Technology, Pleasanton CA, USA, Catalog # A04408)

Host

Rabbit

Contents

GITRL Antibody is supplied in PBS containing 0.02% sodium azide.

Clonality

Polyclonal

Isotype

IgG

Immunogen

GITRL antibody was raised against purified recombinant human GITR ligand.

Reactive Species

A04408 is reactive to TNFSF18 in Human, Mouse

Observed Molecular Weight

27 kD

Calculated molecular weight

22.7 kDa

Background of TNFSF18

The tumor necrosis factor (TNF) and TNF receptor (TNFR) gene superfamilies regulate numerous biological functions including cell proliferation, differentiation, and survival through regulating the activation of the transcription factor NF-κB and various mitogen-activated protein kinases. The glucocorticoid-induced tumor necrosis factor receptor (GITR) is an emerging member of this family that is expressed on CD4+ CD25+ regulatory T cells and appears to have crucial immune regulation functions. Its ligand GITRL is expressed in endothelial and antigen-presenting cells and can activate NF-κB, induce both pro- and anti-apoptotic effects, inhibit the suppressive activity of regulatory T cells, and co-stimulate responder T cells through GITR. Dominant negative forms of NIK and TRAF2 expressed in transfected 293 cells substantially inhibited NF-κB activation, suggesting that the GITRL-GITR pathway involves both NIK and TRAF2.

Antibody Validation

Boster validates all antibodies on WB, IHC, ICC, Immunofluorescence, and ELISA with known positive control and negative samples to ensure specificity and high affinity, including thorough antibody incubations.

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Applications

A04408 is guaranteed for ELISA, WB Boster Guarantee

Assay Dilutions Recommendation

The recommendations below provide a starting point for assay optimization. The actual working concentration varies and should be decided by the user.

WB: 1-4 μg/mL
Antibody validated: Western Blot in human and mouse samples. All other applications and species not yet tested.

Validation Images & Assay Conditions

See full target information TNFSF18

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