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Product Info Summary
| SKU: | M04901 |
|---|---|
| Size: | 0.1 mg |
| Reactive Species: | Human |
| Host: | Mouse |
| Application: | Flow Cytometry, IP, IHC-F |
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Product info
Product Name
Anti-Hu CD102 Purified ICAM2 Monoclonal Antibody
SKU/Catalog Number
M04901
Size
0.1 mg
Form
Liquid
Description
Boster Bio Anti-Hu CD102 Purified ICAM2 Monoclonal Antibody (Catalog# M04901). Tested in Flow Cytometry, IP, IHC-F application(s). This antibody reacts with Human.
Storage & Handling
Store at 2-8°C. Do not freeze.
Cite This Product
Anti-Hu CD102 Purified ICAM2 Monoclonal Antibody (Boster Biological Technology, Pleasanton CA, USA, Catalog # M04901)
Host
Mouse
Contents
Phosphate buffered saline (PBS), pH 7.4, 15 mM sodium azide
Clonality
Monoclonal
Clone Number
CBR-IC2/2
Isotype
Mouse IgG2a
Immunogen
Human CD102 cDNA transfected COS cells. The mouse monoclonal antibody CBR-IC2/2 recognizes an extracellular epitope of CD102 (ICAM-2), an approximately 55 kDa type I transmembrane glycoprotein expressed mainly on vascular endothelial cells and folicular dendritic cells, in lower amount on lymphocytes, monocytes and platelets.
Cross-reactivity
This antibody does not cross-react with Thy-1.1 alloantigen.
Reactive Species
M04901 is reactive to ICAM2 in Human
Observed Molecular Weight
42 kDa
Calculated molecular weight
30.7 kDa
Background of ICAM2
CD102 / ICAM-2 (intracellular cell adhesion molecule-2), a counter receptor of LFA-1 (CD11a/CD18), is a transmembrane glycoprotein with two extracellular IgC-like domains and intracellular C-terminal tail. It is involved in lymphocyte recirculation and homing to the sites of inflammation. Through interaction with integrins it provides to the immune cells costimulatory signals. Expression of CD102 on blood cells (lymphocytes, monocytes, thrombocytes) is lower than on endothelium and follicular dendritic cells. CD102 levels are upregulated in lymph nodes with malignant infiltration.
Antibody Validation
Boster validates all antibodies on WB, IHC, ICC, Immunofluorescence, and ELISA with known positive control and negative samples to ensure specificity and high affinity, including thorough antibody incubations.
Application & Images
Applications
M04901 is guaranteed for Flow Cytometry, IP, IHC-F Boster Guarantee
Assay Dilutions Recommendation
The recommendations below provide a starting point for assay optimization. The actual working concentration varies and should be decided by the user.
Flow cytometry: 2-4 μg/ml.
Validation Images & Assay Conditions
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Separation of human lymphocytes stained using anti-human CD102 (CBR-IC2/2) purified antibody (concentration in sample 0.6 µg/ml, GAM APC) from lymphocytes unstained by primary antibody (GAM APC, black-dashed) in flow cytometry analysis (surface staining) of human peripheral whole blood.
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Flow cytometry surface staining pattern of human peripheral whole blood stained using anti-human CD102 (CBR-IC2/2) purified antibody (concentration in sample 0.6 µg/ml) GAM APC.
Specific Publications For Anti-Hu CD102 Purified ICAM2 Monoclonal Antibody (M04901)
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