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Product Info Summary
| SKU: | M01188 |
|---|---|
| Size: | 0.1 mg |
| Reactive Species: | Human |
| Host: | Mouse |
| Application: | Flow Cytometry, IP, IHC |
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Product info
Product Name
Anti-Hu CD1c Purified Monoclonal Antibody
SKU/Catalog Number
M01188
Size
0.1 mg
Form
Liquid
Description
Boster Bio Anti-Hu CD1c Purified Monoclonal Antibody (Catalog# M01188). Tested in Flow Cytometry, IP, IHC application(s). This antibody reacts with Human.
Storage & Handling
Store at 2-8°C. Do not freeze.
Cite This Product
Anti-Hu CD1c Purified Monoclonal Antibody (Boster Biological Technology, Pleasanton CA, USA, Catalog # M01188)
Host
Mouse
Contents
Phosphate buffered saline (PBS), pH 7.4, 15 mM sodium azide
Clonality
Monoclonal
Clone Number
L161
Isotype
Mouse IgG1 kappa
Immunogen
Human thymocytes. The mouse monoclonal antibody L161 recognizes an extracellular epitope of CD1c, (R7), a 43 kDa type I glycoprotein associated with beta2-microglobulin. It is expressed on cortical thymocytes (strongly), Langerhans cells, dendritic cells, B and some T cells.
Reactive Species
M01188 is reactive to CD1C in Human
Observed Molecular Weight
42 kDa
Calculated molecular weight
37.7 kDa
Background of CD1C
CD1c (also known as R7 or BDCA1) together with CD1a and b, belongs to group 1 of CD1 antigens. These non-classical MHC-like glycoproteins serve as antigen-presenting molecules for a subset of T cells that responds to specific lipids and glycolipids found in the cell walls of bacterial pathogens or self-glycolipid antigens such as gangliosides, and they have also roles in antiviral immunity. The trafficking routes of the particular CD1 types differ and correspond to their ability to bind and present different groups of antigens. CD1c is unique in its ability to present e.g. mycobacterial phosphoketides and polyisoprenoids. CD1c is the only CD1 isoform that has been shown to interact both with alpha/beta and gamma/delta T cells.
Antibody Validation
Boster validates all antibodies on WB, IHC, ICC, Immunofluorescence, and ELISA with known positive control and negative samples to ensure specificity and high affinity, including thorough antibody incubations.
Application & Images
Applications
M01188 is guaranteed for Flow Cytometry, IP, IHC Boster Guarantee
Assay Dilutions Recommendation
The recommendations below provide a starting point for assay optimization. The actual working concentration varies and should be decided by the user.
Flow cytometry: 1-4 μg/ml.
Validation Images & Assay Conditions
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Flow cytometry multicolor surface staining of human lymphocytes stained using anti-human CD1c (L161) purified antibody (concentration in sample 0,33 µg/ml, GAM APC) and anti-human CD19 (LT19) APC antibody (20 µl reagent / 100 µl of peripheral whole blood).
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Separation of human CD1c positive CD19 positive lymphocytes (red-filled) from neutrophil granulocytes (black-dashed) in flow cytometry analysis (surface staining) of human peripheral whole blood using anti-human CD1c (L161) purified antibody (concentration in sample 0,33 µg/ml, GAM APC).
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Flow cytometry surface staining pattern of human peripheral whole blood stained using anti-human CD1c (L161) purified antibody (concentration in sample 0,33 µg/ml, GAM APC).
Specific Publications For Anti-Hu CD1c Purified Monoclonal Antibody (M01188)
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