Anti-Human Emerin DyLight® 550 conjugated EMD Antibody(monoclonal, 5A10)
Mouse IgG Monoclonal Anti-Human Emerin Antibody DyLight® 550 Conjugated, Flow Validated.
Anti-Human Emerin DyLight® 550 conjugated EMD Antibody(monoclonal, 5A10) Info At A Glance
|Product Name||Anti-Human Emerin DyLight® 550 conjugated EMD Antibody(monoclonal, 5A10)
See all Emerin primary antibodies, ELISA kits and proteins
|Storage & Handling||At 2-8°C for one year. Protect from light. Do not freeze.|
|Description||Mouse IgG Monoclonal Anti-Human Emerin Antibody DyLight® 550 Conjugated, Flow Validated.|
|Cite This Product||Anti-Human Emerin DyLight® 550 conjugated EMD Antibody(monoclonal, 5A10) (Boster Biological Technology, Pleasanton CA, USA, Catalog # M00714-Dyl550)|
*Our Boster Guarantee covers the use of this product in the above tested applications.
*Innovating Scientists reward: if you test this antibody on a species or application not listed above and share with us your results, we will provide you a full credit to purchase Boster products.
|Immunogen||A synthetic peptide corresponding to a sequence at the N-terminus of human Emerin (1-48aa MDNYADLSDTELTTLLRRYNIPHGPVVGSTRRLYEKKIFEYETQRRRL), different from the related mouse sequence by eight amino acids, and from the related rat sequence by nine amino acids.|
|Cross Reactivity||No cross reactivity with other proteins.|
Gene/Protein Basic Information For EMD (Source: Uniprot.org, NCBI)
|NCBI Gene Id||2010|
|Species Of This Entry||Human|
|Alternative Names||Emerin|emerin; Emery-Dreifuss muscular dystrophy; LEM domain containing 5; STAEDMDLEMD5|
|Post Tranlational Modifications||Phosphorylation; Cleavage; Reduction; Oxidation; Demethylation; Hydroxylation; Deiodination; Dephosphorylation; Nitration; Glycosylation; Bromination|
|Subcellular Localization||Nucleus inner membrane; Single-pass membrane protein; Nucleoplasmic side. Nucleus outer membrane. Colocalized with BANF1 at the central region of the assembling nuclear rim, near spindle-attachment sites. The accumulation of different intermediates of prelamin-A/C (non-farnesylated or carboxymethylated farnesylated prelamin-A/C) in fibroblasts modify its localization in the nucleus.|
|Gene Location||Xq28, on Chromasome X, gene sequence: NC_000023.11 (154379236..154381523)|
*if product is indicated to react with multiple species, protein info is based on the gene entry specified above in "species".
Ontology For EMD (Source: Uniprot.org, NCBI)
|Protein Function||Stabilizes and promotes the formation of a nuclear actin cortical network. Stimulates actin polymerization in vitro by binding and stabilizing the pointed end of growing filaments. Inhibits beta-catenin activity by preventing its accumulation in the nucleus. Acts by influencing the nuclear accumulation of beta- catenin through a CRM1-dependent export pathway. Links centrosomes to the nuclear envelope via a microtubule association. EMD and BAF are cooperative cofactors of HIV-1 infection. Association of EMD with the viral DNA requires the presence of BAF and viral integrase. The association of viral DNA with chromatin requires the presence of BAF and EMD. Required for proper localization of non-farnesylated prelamin-A/C.|
|Tissue Specificity||Skeletal muscle, heart, colon, testis, ovary and pancreas.|
|Interacting Proteins||ABT1; ACTB; AEN; BANF1; BCLAF1; BYSL; CATSPER1; CCDC155; CEP70; CTNNB1; EFHC2; FATE1; LUZP4; MAB21L3; MEOX2; PAK5; SH3GL2; STX4; Sun1; SUN2; TRAF3IP3; TRIM42; VAPB; ZFP64; ZNF165; ZNF232|
|Related Diseases||Alveolar Bone Loss; Gingival Recession; Periodontal Attachment Loss; Periodontal Pocket; Periodontitis; Neoplasms; Cardiac Arrest; Hemorrhage; Chronic Periodontitis; Dental Plaque; Malignant Neoplasms; Pain; Electromechanical Dissociation; Cardiac Fibrillation; Cardiac Arrhythmia; Heart Failure; Ventricular Fibrillation; Periodontal Diseases; Tissue Adhesions; Muscle Twitch|
|Related Pathways||Regeneration; Tissue Regeneration; Wound Healing; Cell Proliferation; Transport; Secretion; Sensitization; Angiogenesis; Cell Growth; Localization; Cell Differentiation; Cell Adhesion; Reflex; Muscle Contraction; Cell Cycle; Pathogenesis; Cell Migration; Osteoblast Differentiation; Inflammatory Response; Dehiscence|
|Scientific References||PMID: 7894480 by Bione S., et al. Identification of a novel X-linked gene responsible for Emery- Dreifuss muscular dystrophy.|
PMID: 8733135 by Chen E.Y., et al. Long-range sequence analysis in Xq28: thirteen known and six candidate genes in 219.4 kb of high GC DNA between the RCP/GCP and G6PD loci.
Our Boster Quality Guarantee for Anti-Human Emerin DyLight® 550 conjugated EMD Antibody(monoclonal, 5A10) covers its use in the following applications.Flow Cytometry, 1-3μg/1x106 cells
*The recommended dilution ratios/concentrations are for reference only and optimal dilutions/concentrations should be determined by the end user.
Boster provides comprehensive technical information for WB, IHC/IF/ICC, Flow Cytometry sample preparation protocols, assay protocols, troubleshooting tips and assay optimization tips.
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