Anti-Human PDCD10 DyLight® 488 conjugated Antibody

Product Name

Anti-Human PDCD10 DyLight® 488 conjugated Antibody

View all PDCD10 Antibodies

SKU/Catalog Number

A01879-Dyl488

Size

100 μg/vial

Form

Liquid

Description

Boster Bio Anti-Human PDCD10 DyLight® 488 conjugated Antibody catalog # A01879-Dyl488. Tested in Flow Cytometry applications. This antibody reacts with Human.

Storage & Handling

At -20°C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.

Cite This Product

Anti-Human PDCD10 DyLight® 488 conjugated Antibody (Boster Biological Technology, Pleasanton CA, USA, Catalog # A01879-Dyl488)

Host

Rabbit

Contents

Each vial contains 50% glycerol, 0.9% NaCl, 0.2% Na2HPO4, 0.02% NaN3.

Clonality

Polyclonal

Isotype

Rabbit IgG

Immunogen

E. coli-derived human PDCD10 recombinant protein (Position: M1-A212).

*Blocking peptide can be purchased. Costs vary based on immunogen length. Contact us for pricing.

Cross-reactivity

No cross-reactivity with other proteins.

Reactive Species

A01879-Dyl488 is reactive to PDCD10 in Human

Applications

A01879-Dyl488 is guaranteed for Flow Cytometry Boster Guarantee

Observed Molecular Weight

39 kDa

Calculated molecular weight

24.702kDa

Background of PDCD10

Programmed cell death protein 10 is a protein that in humans is encoded by the PDCD10 gene. This gene encodes an evolutionarily conserved protein associated with cell apoptosis. The protein interacts with the serine/threonine protein kinase MST4 to modulate the extracellular signal-regulated kinase (ERK) pathway. It also interacts with and is phosphoryated by serine/threonine kinase 25, and is thought to function in a signaling pathway essential for vascular developent. Mutations in this gene are one cause of cerebral cavernous malformations, which are vascular malformations that cause seizures and cerebral hemorrhages. Multiple alternatively spliced variants, encoding the same protein, have been identified.

Antibody Validation

Boster validates all antibodies on WB, IHC, ICC, Immunofluorescence, and ELISA with known positive control and negative samples to ensure specificity and high affinity, including thorough antibody incubations.

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Assay Dilutions Recommendation

The recommendations below provide a starting point for assay optimization. The actual working concentration varies and should be decided by the user.

Flow Cytometry, 1-3μg/1x10⁶ cells

Validation Images & Assay Conditions

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Figure 1. Flow Cytometry analysis of K562 cells using anti-Human PDCD10 antibody (A01879-Dyl488).
Overlay histogram showing K562 cells stained with A01879-Dyl488 (Blue line).The cells were blocked with 10% normal goat serum. And then incubated with rabbit anti-Human PDCD10 Antibody (A01879-Dyl488,1μg/1x10⁶ cells) for 30 min at 20°C. Isotype control antibody (Green line) was rabbit IgG (1μg/1x10⁶) used under the same conditions. Unlabelled sample (Red line) was also used as a control.

Gene/Protein Information For PDCD10 (Source: Uniprot.org, NCBI)

Alternative Names

apoptosis-related protein 15; cerebral cavernous malformations 3; MGC1212; MGC24477; programmed cell death 10; programmed cell death protein 10; TF-1 cell apoptosis-related protein 15; TFAR15CCM3Cerebral cavernous malformations 3 protein PDCD10 CCM3, TFAR15 programmed cell death 10 programmed cell death protein 10|TF-1 cell apoptosis-related protein 15|apoptosis-related protein 15|cerebral cavernous malformations 3 protein

For more info on PDCD10, check out the PDCD10 Infographic

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In this infographic, you will see the following information for PDCD10: database IDs, superfamily, protein function, synonyms, molecular weight, chromosomal locations, tissues of expression, subcellular locations, post-translational modifications, and related diseases, research areas & pathways. If you want to see more information included, or would like to contribute to it and be acknowledged, please contact [email protected].

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