Anti-MSH6/Gtbp Rabbit Monoclonal Antibody

Product Name

Anti-MSH6/Gtbp Rabbit Monoclonal Antibody

View all MSH6 Antibodies

SKU/Catalog Number

M00553

Size

100 μl

Form

Liquid

Description

Boster Bio Anti-MSH6/Gtbp Rabbit Monoclonal Antibody catalog # M00553. Tested in WB, IHC, ICC/IF applications. This antibody reacts with Human, Mouse, Rat.

Storage & Handling

Store at -20°C for one year. For short term storage and frequent use, store at 4°C for up to one month. Avoid repeated freeze-thaw cycles.

Cite This Product

Anti-MSH6/Gtbp Rabbit Monoclonal Antibody (Boster Biological Technology, Pleasanton CA, USA, Catalog # M00553)

Host

Rabbit

Contents

Rabbit IgG in phosphate buffered saline, pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol, 0.4-0.5mg/ml BSA.

Clonality

Monoclonal

Clone Number

AEB-13

Isotype

Rabbit IgG

Immunogen

A synthesized peptide derived from human MSH6

*Blocking peptide can be purchased. Costs vary based on immunogen length. Contact us for pricing.

Reactive Species

M00553 is reactive to MSH6 in Human, Mouse, Rat

Applications

M00553 is guaranteed for IF, IHC, ICC, WB Boster Guarantee

Observed Molecular Weight

42 kDa, 48 kDa

Calculated molecular weight

152.786kDa

Background of MSH6

Dynamin-related GTPase required for mitochondrial fusion and regulation of apoptosis. May form a diffusion barrier for proteins stored in mitochondrial cristae. Proteolytic processing in response to intrinsic apoptotic signals may lead to disassembly of OPA1 oligomers and release of the caspase activator cytochrome C (CYCS) into the mitochondrial intermembrane space.

Antibody Validation

Boster validates all antibodies on WB, IHC, ICC, Immunofluorescence, and ELISA with known positive control and negative samples to ensure specificity and high affinity, including thorough antibody incubations.

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Reconsitution

Restore with deionized water (or equivalent) for reconstitution volume of 1.0 mL

Assay Dilutions Recommendation

The recommendations below provide a starting point for assay optimization. The actual working concentration varies and should be decided by the user.

WB 1:500-1:2000
IHC 1:50-1:200
ICC/IF 1:50-1:200

Validation Images & Assay Conditions

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All lanes use the Antibody at 1:1K dilution for 1 hour at room temperature.

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Western blot analysis of MSH6 in SW480 cell lysate.

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Immunohistochemical analysis of paraffin-embedded human colon carcinoma, using MSH6 Antibody.

Gene/Protein Information For MSH6 (Source: Uniprot.org, NCBI)

Alternative Names

DNA mismatch repair protein Msh6; G/T mismatch-binding protein; GTBPHNPCC5; GTMBP; hMSH6; HSAP; mutS (E. coli) homolog 6; mutS homolog 6 (E. coli); MutS-alpha 160 kDa subunit; p160; sperm-associated protein MSH6 GTBP, GTMBP, HNPCC5, HSAP, MMRCS3, p160 mutS homolog 6 DNA mismatch repair protein Msh6|G/T mismatch-binding protein|mutS protein homolog 6|mutS-alpha 160 kDa subunit|sperm-associated protein

For more info on MSH6, check out the MSH6 Infographic

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In this infographic, you will see the following information for MSH6: database IDs, superfamily, protein function, synonyms, molecular weight, chromosomal locations, tissues of expression, subcellular locations, post-translational modifications, and related diseases, research areas & pathways. If you want to see more information included, or would like to contribute to it and be acknowledged, please contact [email protected].

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