Product Info Summary
SKU: | A08686 |
---|---|
Size: | 0.1 mg |
Reactive Species: | Human, Mouse, Rat |
Host: | Rabbit |
Application: | ELISA, IF, ICC, WB |
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Product info
Product Name
Anti-PARL Antibody
SKU/Catalog Number
A08686
Size
0.1 mg
Form
Liquid
Description
Boster Bio Anti-PARL Antibody (Catalog # A08686). Tested in ELISA, WB, ICC, IF applications. This antibody reacts with Human, Mouse, Rat.
Storage & Handling
PARL antibody can be stored at 4°C for three months and -20°C, stable for up to one year. Avoid repeated freeze-thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Cite This Product
Anti-PARL Antibody (Boster Biological Technology, Pleasanton CA, USA, Catalog # A08686)
Host
Rabbit
Contents
PARL Antibody is supplied in PBS containing 0.02% sodium azide.
Clonality
Polyclonal
Clone Number
SK7
Isotype
IgG
Immunogen
PARL antibody was raised against a 15 amino acid synthetic peptide from near the amino terminus of human PARL. The immunogen is located within amino acids 40 - 90 of PARL.
*Blocking peptide can be purchased. Costs vary based on immunogen length. Contact us for pricing.
Cross-reactivity
Multiple isoforms of FNIP2 are known to exist. This antibody is predicted to not cross-react with FNIP1.
Reactive Species
A08686 is reactive to PARL in Human, Mouse, Rat
Applications
A08686 is guaranteed for ELISA, IF, ICC, WB Boster Guarantee
Observed Molecular Weight
68 kDa
Calculated molecular weight
42.19kDa
Background of PARL
PARL is a mitochondrial integral membrane protein and a member of the highly conserved rhomboid superfamily of membrane proteins. PARL is required for the control of apoptosis during postnatal growth and is required for the processing of OPA1, a protein that prevents the release of cytochrome C from the mitochondria in response to apoptotic signals. In lymphocytes and neurons, PARL's association with other proteins, such as the Bcl-2 family-related protein Hax1 and Omi can lead to the proteolytic processing of Omi by PARL, preventing the accumulation of Bax, thereby suppressing apoptosis. Variations in this gene have been associated with increased risk for type 2 diabetes. PARL may also play a role in the progression of Alzheimer's disease through its associations with presenilin-1 and -2. Multiple isoforms of PARL are known to exist.
Antibody Validation
Boster validates all antibodies on WB, IHC, ICC, Immunofluorescence, and ELISA with known positive control and negative samples to ensure specificity and high affinity, including thorough antibody incubations.
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Assay dilution & Images
Assay Dilutions Recommendation
The recommendations below provide a starting point for assay optimization. The actual working concentration varies and should be decided by the user.
PARL antibody can be used for detection of PARL by Western blot at 1 - 2 μg/mL. Despite its predicted molecular weight of ~42kDa, PARL is observed at a higher molecular weight in SDS-PAGE. Antibody can also be used for immunocytochemistry starting at 2.5 μg/mL. For immunofluorescence start at 20 μg/mL.
Antibody validated: Western Blot in mouse samples; Immunocytochemistry in mouse samples and Immunofluorescence in mouse samples. All other applications and species not yet tested. Optimal dilutions for each application should be determined by the researcher.
Validation Images & Assay Conditions
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Western blot analysis of PARL in 3T3 cell lysate with PARL antibody at (A) 1 and (B) 2 μg/mL.
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Immunocytochemistry of PARL in 3T3 cells with PARL antibody at 2.5 μg/mL.
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Immunofluorescence of PARL in 3T3 cells with PARL antibody at 2.50 μg/mL.
Protein Target Info & Infographic
Gene/Protein Information For PARL (Source: Uniprot.org, NCBI)
Gene Name
PARL
Full Name
Presenilins-associated rhomboid-like protein, mitochondrial
Weight
42.19kDa
Superfamily
peptidase S54 family
Alternative Names
EC 3.4.21.105; mitochondrial; PARL; presenilin associated, rhomboid-like; PRO2207; PSARL1; RHBDS1; rhomboid 7 homolog 1 PARL PRO2207, PSARL, PSARL1, PSENIP2, RHBDS1 presenilin associated rhomboid like presenilins-associated rhomboid-like protein, mitochondrial|mitochondrial intramembrane-cleaving protease PARL|rhomboid 7 homolog 1
*If product is indicated to react with multiple species, protein info is based on the gene entry specified above in "Species".For more info on PARL, check out the PARL Infographic
We have 30,000+ of these available, one for each gene! Check them out.
In this infographic, you will see the following information for PARL: database IDs, superfamily, protein function, synonyms, molecular weight, chromosomal locations, tissues of expression, subcellular locations, post-translational modifications, and related diseases, research areas & pathways. If you want to see more information included, or would like to contribute to it and be acknowledged, please contact [email protected].
Specific Publications For Anti-PARL Antibody (A08686)
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No publications found for A08686
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