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Product Info Summary
| SKU: | A00639 |
|---|---|
| Size: | 0.1 mg |
| Reactive Species: | Human, Mouse, Rat |
| Host: | Rabbit |
| Application: | ELISA, WB |
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Product info
Product Name
Anti-Partner and localizer of BRCA2 PALB2 Antibody
SKU/Catalog Number
A00639
Size
0.1 mg
Form
Liquid
Description
Boster Bio Anti-Partner and localizer of BRCA2 PALB2 Antibody (Catalog # A00639). Tested in ELISA, WB applications. This antibody reacts with Human, Mouse, Rat.
Storage & Handling
PALB2 antibody can be stored at 4°C for three months and -20°C, stable for up to one year. Avoid repeated freeze-thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Cite This Product
Anti-Partner and localizer of BRCA2 PALB2 Antibody (Boster Biological Technology, Pleasanton CA, USA, Catalog # A00639)
Host
Rabbit
Contents
PALB2 Antibody is supplied in PBS containing 0.02% sodium azide.
Clonality
Polyclonal
Isotype
IgG
Immunogen
PALB2 antibody was raised against a 15 amino acid synthetic peptide from near the carboxy terminus of human PALB2. The immunogen is located within amino acids 940 - 990 of PALB2.
Cross-reactivity
At least four isoforms of PALB2 are known to exist; this antibody will detect all four isoforms.
Reactive Species
A00639 is reactive to PALB2 in Human, Mouse, Rat
Observed Molecular Weight
68 kDa
Calculated molecular weight
131.3 kDa
Background of PALB2
The breast cancer early onset proteins BRCA1 and BRCA2 are central to the repair of DNA damage by homologous recombination and are strongly associated with inherited breast and ovarian cancer. The protein PALB2 is required for the localization of BRCA2 to sites of DNA damage and like BRCA1 and 2 is a breast cancer susceptibility gene. PALB2 is thought to function through directly binding to BRCA1, which allows the PALB2 protein to organize BRCA2 and the recombinase RAD51 at the site of DNA damage. Analysis of the BRCA1-PALB2-BRCA2-RAD51network may allow predictions to be made of the responsiveness of a particular tumor to therapeutic treatments.
Antibody Validation
Boster validates all antibodies on WB, IHC, ICC, Immunofluorescence, and ELISA with known positive control and negative samples to ensure specificity and high affinity, including thorough antibody incubations.
Application & Images
Applications
A00639 is guaranteed for ELISA, WB Boster Guarantee
Assay Dilutions Recommendation
The recommendations below provide a starting point for assay optimization. The actual working concentration varies and should be decided by the user.
PALB2 antibody can be used for detection of PALB2 by Western blot at 1 - 2 μg/mL.
Antibody validated: Western Blot in human samples. All other applications and species not yet tested. Optimal dilutions for each application should be determined by the researcher.
Validation Images & Assay Conditions
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Western blot analysis of PALB2 in SK-N-SH cell lysate with PALB2 antibody at 1 μg/mL.
Specific Publications For Anti-Partner and localizer of BRCA2 PALB2 Antibody (A00639)
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