Proteasome subunit alpha type-3 (PSMA3)

Component of the 20S core proteasome complex involved in the proteolytic degradation of most intracellular proteins. This complex plays numerous essential roles within the cell by associating with different regulatory particles.

Connected with two 19S regulatory particles, forms the 26S proteasome and so participates in the ATP-dependent degradation of ubiquitinated proteins. The 26S proteasome plays a key role in the maintenance of protein homeostasis by eliminating misfolded or damaged proteins which could impair cellular functions, and by eliminating proteins whose functions are no longer required.