Anti-Phospho-Filamin 1 (Ser2152) FLNA Antibody

Product Name

Anti-Phospho-Filamin 1 (Ser2152) FLNA Antibody

View all Filamin A Antibodies

SKU/Catalog Number

P00502

Size

100 µl

Form

Liquid

Description

Boster Bio Anti-Phospho-Filamin 1 (Ser2152) FLNA Antibody (Catalog # P00502). Tested in WB, IHC, ELISA applications. This antibody reacts with Human, Mouse, Rat, Monkey.

Storage & Handling

Store at -20°C for one year. For short term storage and frequent use, store at 4°C for up to one month. Avoid repeated freeze-thaw cycles.

Cite This Product

Anti-Phospho-Filamin 1 (Ser2152) FLNA Antibody (Boster Biological Technology, Pleasanton CA, USA, Catalog # P00502)

Host

Rabbit

Contents

Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Clonality

Polyclonal

Isotype

IgG

Immunogen

Synthesized peptide derived from human Filamin 1 around the phosphorylation site of S2152.

*Blocking peptide can be purchased. Costs vary based on immunogen length. Contact us for pricing.

Cross-reactivity

No cross reactivity with other proteins.

Reactive Species

P00502 is reactive to FLNA in Human, Monkey, Mouse, Rat

Applications

P00502 is guaranteed for ELISA, IHC, WB Boster Guarantee

Observed Molecular Weight

Calculated molecular weight

280.739kDa

Background of Filamin A

Probable regulator of the Hippo/SWH (Sav/Wts/Hpo) signaling pathway, a signaling pathway that plays a pivotal role in tumor suppression by restricting proliferation and promoting apoptosis. Along with WWC1 can synergistically induce the phosphorylation of LATS1 and LATS2 and can probably function in the regulation of the Hippo/SWH (Sav/Wts/Hpo) signaling pathway. May act as a membrane stabilizing protein. May inhibit PI3 kinase by binding to AGAP2 and impairing its stimulating activity.

Guang-Hui Xiao, et al. (2005) Mol. Cell. Biol ; 25: 2384 - 2394.
Hi-Su Yang, et al. (2006) Cancer Res ; 66: 2708 - 2715.
R Bohni, et al. (1994) J. Biol. Chem ; 269: 14541 - 14545.
Adam J. Ratner, et al. (2001) J. Biol. Chem ; 276: 19267 - 19275.

Antibody Validation

Boster validates all antibodies on WB, IHC, ICC, Immunofluorescence, and ELISA with known positive control and negative samples to ensure specificity and high affinity, including thorough antibody incubations.

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Assay Dilutions Recommendation

The recommendations below provide a starting point for assay optimization. The actual working concentration varies and should be decided by the user.

Western blotting: 1/500 - 1/2000
Immunohistochemistry: 1/100 - 1/300
ELISA: 1/10000
Not yet tested in other applications.

Validation Images & Assay Conditions

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Western Blot analysis of HuvEc cells using Phospho-Filamin 1 (S2152) Polyclonal antibody

Gene/Protein Information For FLNA (Source: Uniprot.org, NCBI)

Alternative Names

ABP-280DKFZp434P031; ABPX; actin binding protein 280; Actin-binding protein 280; alpha-filamin; CVD1; EC 2.1.1.43; EC 6.3.4.4; Endothelial actin-binding protein; filamin A, alpha (actin binding protein 280); filamin A, alpha; filamin-1; filamin-A; FLN; FLN1OPD; FLN-A; FMD; MNS; NHBP; Non-muscle filamin; OPD1; OPD2; XLVD; XMVD FLNA ABP-280, ABPX, CSBS, CVD1, FGS2, FLN, FLN-A, FLN1, FMD, MNS, NHBP, OPD, OPD1, OPD2, XLVD, XMVD filamin A filamin-A|actin binding protein 280|alpha-filamin|endothelial actin-binding protein|epididymis secretory sperm binding protein|filamin A, alpha|filamin-1|non-muscle filamin

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