Product Info Summary
SKU: | A05639-1 |
---|---|
Size: | 100ul |
Reactive Species: | Human, Mouse |
Host: | Rabbit |
Application: | ELISA, IHC, WB |
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Product info
Product Name
Anti-Plakophilin 4 PKP4 Antibody
View all Plakophilin 4 Antibodies
SKU/Catalog Number
A05639-1
Size
100ul
Form
Liquid
Description
Boster Bio Anti-Plakophilin 4 PKP4 Antibody catalog # A05639-1. Tested in ELISA, IHC, WB applications. This antibody reacts with Human, Mouse.
Storage & Handling
Store at -20°C for one year. For short term storage and frequent use, store at 4°C for up to one month. Avoid repeated freeze-thaw cycles.
Cite This Product
Anti-Plakophilin 4 PKP4 Antibody (Boster Biological Technology, Pleasanton CA, USA, Catalog # A05639-1)
Host
Rabbit
Contents
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Clonality
Polyclonal
Isotype
IgG
Immunogen
Synthesized peptide derived from human Plakophilin 4
*Blocking peptide can be purchased. Costs vary based on immunogen length. Contact us for pricing.
Reactive Species
A05639-1 is reactive to PKP4 in Human, Mouse
Applications
A05639-1 is guaranteed for ELISA, IHC, WB Boster Guarantee
Observed Molecular Weight
111 kDa
Calculated molecular weight
131.868kDa
Background of Plakophilin 4
Rapidly and transiently inhibited by phosphorylation following the generation of DNA double-stranded breaks during S-phase. This is cell cycle checkpoint and ATM-pathway dependent and appears to regulate processes involved in chromatin assembly. Isoform 3 phosphorylates and enhances the stability of the t-SNARE SNAP23, augmenting its assembly with syntaxin. Isoform 3 protects the cells from the ionizing radiation by facilitating the repair of DSBs. In vitro, phosphorylates histone H3 at 'Ser-10'.
Yamakawa A., Gene 202:193-201(1997).
Sillje H.H.W., EMBO J. 18:5691-5702(1999).
Cabaniols J.-P., Mol. Biol. Cell 10:4033-4041(1999).
Antibody Validation
Boster validates all antibodies on WB, IHC, ICC, Immunofluorescence, and ELISA with known positive control and negative samples to ensure specificity and high affinity, including thorough antibody incubations.
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Assay dilution & Images
Assay Dilutions Recommendation
The recommendations below provide a starting point for assay optimization. The actual working concentration varies and should be decided by the user.
WB 1:500-1:2000
IHC 1:100-1:300
ELISA 1:5000
Validation Images & Assay Conditions
Click image to see more details
Figure 1. Western blotting validation for Anti-Plakophilin 4 PKP4 Antibody A05639-1
Western Blot (WB) analysis of Mouse Heart lysis using Plakophilin 4 antibody.Electrophoresis was performed on a SDS-PAGE gel. To determine SDS-PAGE gel concentration
Protein Target Info & Infographic
Gene/Protein Information For PKP4 (Source: Uniprot.org, NCBI)
Gene Name
PKP4
Full Name
Plakophilin-4
Weight
131.868kDa
Superfamily
beta-catenin family
Alternative Names
catenin 4; FLJ42243; p0071FLJ31261; plakophilin 4; plakophilin-4 PKP4 p0071 plakophilin 4 plakophilin-4|catenin 4
*If product is indicated to react with multiple species, protein info is based on the gene entry specified above in "Species".For more info on PKP4, check out the PKP4 Infographic
We have 30,000+ of these available, one for each gene! Check them out.
In this infographic, you will see the following information for PKP4: database IDs, superfamily, protein function, synonyms, molecular weight, chromosomal locations, tissues of expression, subcellular locations, post-translational modifications, and related diseases, research areas & pathways. If you want to see more information included, or would like to contribute to it and be acknowledged, please contact [email protected].
Specific Publications For Anti-Plakophilin 4 PKP4 Antibody (A05639-1)
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No publications found for A05639-1
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