Product Info Summary
SKU: | A11764 |
---|---|
Size: | 0.1 mg |
Reactive Species: | Human, Mouse, Rat |
Host: | Rabbit |
Application: | ELISA, IF, IHC-P, WB |
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Product info
Product Name
Anti-Protein tweety homolog 2 TTYH2 Antibody
SKU/Catalog Number
A11764
Size
0.1 mg
Form
Liquid
Description
Boster Bio Anti-Protein tweety homolog 2 TTYH2 Antibody (Catalog # A11764). Tested in ELISA, WB, IHC-P, IF applications. This antibody reacts with Human, Mouse, Rat.
Storage & Handling
TTYH2 antibody can be stored at 4°C for three months and -20°C, stable for up to one year. Avoid repeated freeze-thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Cite This Product
Anti-Protein tweety homolog 2 TTYH2 Antibody (Boster Biological Technology, Pleasanton CA, USA, Catalog # A11764)
Host
Rabbit
Contents
TTYH2 Antibody is supplied in PBS containing 0.02% sodium azide.
Clonality
Polyclonal
Clone Number
Clone: SK7
Isotype
IgG
Immunogen
TTYH2 antibody was raised against a 14 amino acid synthetic peptide near the amino terminus of human TTYH2. The immunogen is located within amino acids 60 - 110 of TTYH2.
*Blocking peptide can be purchased. Costs vary based on immunogen length. Contact us for pricing.
Cross-reactivity
At least four isoforms of TTYH2 are known to exist; this antibody will only detect the two longest isoforms. This antibody is predicted to not cross-react with other TTYH family members.
Reactive Species
A11764 is reactive to TTYH2 in Human, Mouse, Rat
Applications
A11764 is guaranteed for ELISA, IF, IHC-P, WB Boster Guarantee
Observed Molecular Weight
68 kDa
Calculated molecular weight
58.772kDa
Background of TTYH2
TTYH2 is a member of the tweety family of proteins, a family of chloride anion channels containing five transmembrane regions. TTYH2 is a Ca2+-activated large conductance chloride (Cl-) channel and may play a role in kidney tumorigenesis. It is also upregulated in colon carcinoma and is thought to play a role in cell proliferation and call aggregation, suggesting that TTYH2 may play a role in regulating both proliferation and metastatic potentials of colorectal cancer. The ubiquitin-protein ligase Nedd4-2 binds to and ubiquitinates TTYH2, thereby regulating its cell surface expression and total cellular levels.
Antibody Validation
Boster validates all antibodies on WB, IHC, ICC, Immunofluorescence, and ELISA with known positive control and negative samples to ensure specificity and high affinity, including thorough antibody incubations.
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Assay dilution & Images
Assay Dilutions Recommendation
The recommendations below provide a starting point for assay optimization. The actual working concentration varies and should be decided by the user.
TTYH2 antibody can be used for detection of TTYH2 by Western blot at 1 μg/mL. Antibody can also be used for immunohistochemistry starting at 2.5 μg/mL. For immunofluorescence start at 2.5 μg/mL.
Antibody validated: Western Blot in human samples; Immunohistochemistry in human samples and Immunofluorescence in human samples. All other applications and species not yet tested. Optimal dilutions for each application should be determined by the researcher.
Validation Images & Assay Conditions
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Western blot analysis of TTYH2 in human kidney tissue lysate with TTYH2 antibody at 1 μg/ml
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Immunohistochemistry of TTYH2 in human kidney tissue with TTYH2 antibody at 2.5 μg/mL.
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Immunofluorescence of TTYH2 in human kidney tissue with TTYH2 antibody at 20 μg/mL.
Protein Target Info & Infographic
Gene/Protein Information For TTYH2 (Source: Uniprot.org, NCBI)
Gene Name
TTYH2
Full Name
Protein tweety homolog 2
Weight
58.772kDa
Superfamily
tweety family
Alternative Names
C17orf29; hTTY2; Protein Tweety Homolog 2; Tweety (Drosophila) Homolog 2; Tweety Family Member 2; Tweety Homolog 2 (Drosophila); Tweety Homolog 2 TTYH2 C17orf29 tweety family member 2 protein tweety homolog 2|hTTY2|tweety homolog 2
*If product is indicated to react with multiple species, protein info is based on the gene entry specified above in "Species".For more info on TTYH2, check out the TTYH2 Infographic
We have 30,000+ of these available, one for each gene! Check them out.
In this infographic, you will see the following information for TTYH2: database IDs, superfamily, protein function, synonyms, molecular weight, chromosomal locations, tissues of expression, subcellular locations, post-translational modifications, and related diseases, research areas & pathways. If you want to see more information included, or would like to contribute to it and be acknowledged, please contact [email protected].
Specific Publications For Anti-Protein tweety homolog 2 TTYH2 Antibody (A11764)
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No publications found for A11764
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